Constitutive modelling of composite biopolymer networks
2016 (English)In: Journal of Theoretical Biology, ISSN 0022-5193, E-ISSN 1095-8541, Vol. 395, 51-61 p.Article in journal (Refereed) Published
The mechanical behaviour of biopolymer networks is to a large extent determined at a microstructural level where the characteristics of individual filaments and the interactions between them determine the response at a macroscopic level. Phenomena such as viscoelasticity and strain-hardening followed by strain-softening are observed experimentally in these networks, often due to microstructural changes (such as filament sliding, rupture and cross-link debonding). Further, composite structures can also be formed with vastly different mechanical properties as compared to the indivudal networks. In this present paper, we present a constitutive model presented in a continuum framework aimed at capturing these effects. Special care is taken to formulate thermodynamically consistent evolution laws for dissipative effects. This model, incorporating possible anisotropic network properties, is based on a strain energy function, split into an isochoric and a volumetric part. Generalisation to three dimensions is performed by numerical integration over the unit sphere. Model predictions indicate that the constitutive model is well able to predict the elastic and viscoelastic response of biological networks, and to an extent also composite structures.
Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 395, 51-61 p.
Composite, Actin, Intermediate, Neurofilament, Constitutive
Research subject Solid Mechanics; Biological Physics
IdentifiersURN: urn:nbn:se:kth:diva-173936DOI: 10.1016/j.jtbi.2016.01.034ISI: 000373096700006ScopusID: 2-s2.0-84957991341OAI: oai:DiVA.org:kth-173936DiVA: diva2:856363
FunderSwedish Research Council, A0437201
Updated from "Manuscript" to "Article".
QC 201603112015-09-242015-09-242016-04-25Bibliographically approved