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A Diffusive Homeostatic Signal Maintains Neural Heterogeneity and Responsiveness in Cortical Networks
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB. University of Edinburgh, United Kingdom.
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0002-0550-0739
2015 (English)In: PloS Computational Biology, ISSN 1553-734X, E-ISSN 1553-7358, Vol. 11, no 7, e1004389Article in journal (Refereed) Published
Abstract [en]

Gaseous neurotransmitters such as nitric oxide (NO) provide a unique and often overlooked mechanism for neurons to communicate through diffusion within a network, independent of synaptic connectivity. NO provides homeostatic control of intrinsic excitability. Here we conduct a theoretical investigation of the distinguishing roles of NO-mediated diffusive homeo-stasis in comparison with canonical non-diffusive homeostasis in cortical networks. We find that both forms of homeostasis provide a robust mechanism for maintaining stable activity following perturbations. However, the resulting networks differ, with diffusive homeostasis maintaining substantial heterogeneity in activity levels of individual neurons, a feature disrupted in networks with non-diffusive homeostasis. This results in networks capable of representing input heterogeneity, and linearly responding over a broader range of inputs than those undergoing non-diffusive homeostasis. We further show that these properties are preserved when homeostatic and Hebbian plasticity are combined. These results suggest a mechanism for dynamically maintaining neural heterogeneity, and expose computational advantages of non-local homeostatic processes.

Place, publisher, year, edition, pages
2015. Vol. 11, no 7, e1004389
National Category
Biological Sciences
URN: urn:nbn:se:kth:diva-173990DOI: 10.1371/journal.pcbi.1004389ISI: 000360620100034PubMedID: 26158556ScopusID: 2-s2.0-84938630123OAI: diva2:858227

QC 20151001

Available from: 2015-10-01 Created: 2015-09-24 Last updated: 2015-10-01Bibliographically approved

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