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Structure of potassium channels
KTH, School of Technology and Health (STH). Karolinska Institutet, Sweden.
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Structural Biotechnology. Karolinska Institutet, Sweden.ORCID iD: 0000-0002-3220-9402
2015 (English)In: Cellular and Molecular Life Sciences (CMLS), ISSN 1420-682X, E-ISSN 1420-9071, Vol. 17, no 19, 3677-3693 p.Article, review/survey (Refereed) Published
Abstract [en]

Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but important functions. Since the first atomic structure of a prokaryotic potassium channel (KcsA, a channel from Streptomyces lividans) was determined, tremendous progress has been made in understanding the mechanism of potassium channels and channels conducting other ions. In this review, we discuss the structure of various kinds of potassium channels, including the potassium channel with the pore-forming domain only (KcsA), voltage-gated, inwardly rectifying, tandem pore domain, and ligand-gated ones. The general properties shared by all potassium channels are introduced first, followed by specific features in each class. Our purpose is to help readers to grasp the basic concepts, to be familiar with the property of the different domains, and to understand the structure and function of the potassium channels better.

Place, publisher, year, edition, pages
Springer, 2015. Vol. 17, no 19, 3677-3693 p.
Keyword [en]
Selectivity, Conductivity, Gating, Sensor domain, RCK
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-174208DOI: 10.1007/s00018-015-1948-5ISI: 000361069800006ScopusID: 2-s2.0-84941421455OAI: diva2:860946

QC 20151014

Available from: 2015-10-14 Created: 2015-10-02 Last updated: 2015-12-07Bibliographically approved

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Kuang, QieHebert, Hans
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