Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A proof-of-concept for folate-conjugated and quercetin-anchored pluronic mixed micelles as molecularly modulated polymeric carriers for doxorubicin
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Fibre Technology.ORCID iD: 0000-0002-5444-7276
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.ORCID iD: 0000-0002-7790-8987
2015 (English)In: Polymer, ISSN 0032-3861, E-ISSN 1873-2291, Vol. 74, 193-204 p.Article in journal (Refereed) Published
Abstract [en]

Pluronic, F127 (PEG-PPO-PEG, Mn = 12,500 g/mol) and reverse pluronic, 10R5 (PPO-PEG-PPO, Mn = 2000 g/mol) were molecularly modulated to reach multifunctional mixed micelle systems aiming to overcome some of the inherent weaknesses of pluronic based drug delivery systems. Targeting function was introduced by covalent attachment of folic acid to F127 (F127-FA), while quercetin was anchored to 10R5 (P-Q). The successful syntheses were evidenced by H-1 NMR, FTIR, DSC and UV-Vis. The proof-of-concept for the mixed micelles prepared from the drug anchored pluronics was demonstrated through reduced CMCs, slower release rates and increased Doxorubicin (DOX) encapsulation capacity from similar to 19% to similar to 43%. Quercetin therefore boosted the interactions of DOX with the hydrophobic core of the micelles. This was further evidenced by colloidal probe AFM which demonstrated almost doubled adhesion forces between the DOX coated probe and the quercetin modified pluronic as compared to the plain pluronic. The pre-biological essay of the DOX-modulated mixed micelle demonstrates promising properties. In addition quercetin has previously been proposed as combinatory drug to DOX enhancing its therapeutic function and reducing the side effects to normal cells.

Place, publisher, year, edition, pages
2015. Vol. 74, 193-204 p.
Keyword [en]
Pluronics, Micelles, Druge-polymer interaction
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-175496DOI: 10.1016/j.polymer.2015.08.005ISI: 000361559000022Scopus ID: 2-s2.0-84940204817OAI: oai:DiVA.org:kth-175496DiVA: diva2:862414
Note

QC 20151022

Available from: 2015-10-22 Created: 2015-10-16 Last updated: 2017-12-01Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Authority records BETA

Pettersson, TorbjörnHakkarainen, Minna

Search in DiVA

By author/editor
Hassanzadeh, SalmanFeng, ZhaoxuanPettersson, TorbjörnHakkarainen, Minna
By organisation
Fibre TechnologyPolymer Technology
In the same journal
Polymer
Polymer Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 231 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf