Injectable composites of loose microfibers and gelatin with improved interfacial interaction for soft tissue engineering
2015 (English)In: Polymer, ISSN 0032-3861, E-ISSN 1873-2291, Vol. 74, 224-234 p.Article in journal (Refereed) Published
Poly(L-lactic acid) (PLLA) microfibers were surface functionalized by graft photopolymerization of 2-hydroxyethyl methacrylate (HEMA) onto the fiber surface. Grafted fibers were easily dispersed in enzymatically gelling tyramine-substituted gelatin, forming a homogeneous dispersion without hindering subsequent gelatin crosslinking. The obtained injectable hydrogels showed improved mechanical properties compared to analogues based on non-modified fibers. The composite with 1% (w/v) of surface modified fibers had a three-fold higher shear storage modulus (535.2 +/- 90 Pa) than pure gelatin (184.9 +/- 32 Pa) while no significant increase was observed in the case of non-grafted fiber composites. Moreover, PHEMA grafting on PLLA fibers did not compromise cell viability and proliferation within the hydrogel. The new injectable hydrogels offer improved potential as substrates for the regeneration of soft tissues.
Place, publisher, year, edition, pages
2015. Vol. 74, 224-234 p.
Loose microfibers, Surface-grafting, Poly(L-lactic acid), Enzymatic crosslinking, Injectable hydrogel, Microfiber-hydrogel composite
IdentifiersURN: urn:nbn:se:kth:diva-175497DOI: 10.1016/j.polymer.2015.08.018ISI: 000361559000025ScopusID: 2-s2.0-84940178591OAI: oai:DiVA.org:kth-175497DiVA: diva2:862416
QC 201510222015-10-222015-10-162015-11-25Bibliographically approved