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Injectable composites of loose microfibers and gelatin with improved interfacial interaction for soft tissue engineering
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2015 (English)In: Polymer, ISSN 0032-3861, E-ISSN 1873-2291, Vol. 74, 224-234 p.Article in journal (Refereed) Published
Abstract [en]

Poly(L-lactic acid) (PLLA) microfibers were surface functionalized by graft photopolymerization of 2-hydroxyethyl methacrylate (HEMA) onto the fiber surface. Grafted fibers were easily dispersed in enzymatically gelling tyramine-substituted gelatin, forming a homogeneous dispersion without hindering subsequent gelatin crosslinking. The obtained injectable hydrogels showed improved mechanical properties compared to analogues based on non-modified fibers. The composite with 1% (w/v) of surface modified fibers had a three-fold higher shear storage modulus (535.2 +/- 90 Pa) than pure gelatin (184.9 +/- 32 Pa) while no significant increase was observed in the case of non-grafted fiber composites. Moreover, PHEMA grafting on PLLA fibers did not compromise cell viability and proliferation within the hydrogel. The new injectable hydrogels offer improved potential as substrates for the regeneration of soft tissues.

Place, publisher, year, edition, pages
2015. Vol. 74, 224-234 p.
Keyword [en]
Loose microfibers, Surface-grafting, Poly(L-lactic acid), Enzymatic crosslinking, Injectable hydrogel, Microfiber-hydrogel composite
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-175497DOI: 10.1016/j.polymer.2015.08.018ISI: 000361559000025Scopus ID: 2-s2.0-84940178591OAI: oai:DiVA.org:kth-175497DiVA: diva2:862416
Note

QC 20151022

Available from: 2015-10-22 Created: 2015-10-16 Last updated: 2017-12-01Bibliographically approved

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Edlund, Ulrica

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