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Quest for Missing Proteins: Update 2015 on Chromosome-Centric Human Proteome Project
KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0001-7034-0850
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2015 (English)In: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 14, no 9, 3415-3431 p.Article in journal, Editorial material (Other academic) Published
Abstract [en]

This paper summarizes the recent activities of the Chromosome-Centric Human Proteome Project (C-HPP) consortium, which develops new technologies to identify yet-to-be annotated proteins (termed "missing proteins") in biological samples that lack sufficient experimental evidence at the protein level for confident protein identification. The C-HPP also aims to identify new protein forms that may be caused by genetic variability, post-translational modifications, and alternative splicing. Proteogenomic data integration forms the basis of the C-HPP's activities; therefore, we have summarized some of the key approaches and their roles in the project. We present new analytical technologies that improve the chemical space and lower detection limits coupled to bioinformatics tools and some publicly available resources that can be used to improve data analysis or support the development of analytical assays. Most of this paper's content has been compiled from posters, slides, and discussions presented in the series of C-HPP workshops held during 2014. All data (posters, presentations) used are available at the C-HPP Wild ( and in the Supporting Information.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2015. Vol. 14, no 9, 3415-3431 p.
Keyword [en]
missing proteins, Chromosome-Centric Human Proteome Project, LC-MS, antibody enrichment, proteomics, bioinformatics
National Category
Bioinformatics and Systems Biology Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-174930DOI: 10.1021/pr5013009ISI: 000361087100002PubMedID: 26076068ScopusID: 2-s2.0-84941094441OAI: diva2:862478

QC 20151022

Available from: 2015-10-22 Created: 2015-10-09 Last updated: 2015-10-22Bibliographically approved

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Lundberg, Emma K.
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