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Nanoscopy-imaging life at the nanoscale: a Nobel Prize achievement with a bright future
KTH, School of Engineering Sciences (SCI), Applied Physics, Cell Physics. KTH, Centres, Science for Life Laboratory, SciLifeLab. (Light Microscopy Facil.)ORCID iD: 0000-0002-5584-9170
2015 (English)In: Physica Scripta, ISSN 0031-8949, E-ISSN 1402-4896, Vol. 90, no 10, 108010Article in journal (Refereed) Published
Abstract [en]

A grand scientific prize was awarded last year to three pioneering scientists, for their discovery and development of molecular 'ON-OFF' switching which, when combined with optical imaging, can be used to see the previously invisible with light microscopy. The Royal Swedish Academy of Science announced on October 8th their decision and explained that this achievement-rooted in physics and applied in biology and medicine-was awarded with the Nobel Prize in Chemistry for controlling fluorescent molecules to create images of specimens smaller than anything previously observed with light. The story of how this noble switch in optical microscopy was achieved and how it was engineered to visualize life at the nanoscale is highlighted in this invited comment.

Place, publisher, year, edition, pages
[Blom, Hans] Royal Inst Technol, Adv Light Microscopy Facil, Sci Life Lab, SE-17121 Solna, Sweden. [Bates, Mark] Max Planck Inst Biophys Chem, Dept Nanobiophoton, DE-37077 Gottingen, Germany., 2015. Vol. 90, no 10, 108010
Keyword [en]
2014 nobel prize, chemistry, super-resolution microscopy, single fluorescent molecules, STED, PALM
National Category
Physical Sciences
URN: urn:nbn:se:kth:diva-176357DOI: 10.1088/0031-8949/90/10/108010ISI: 000362529800020ScopusID: 2-s2.0-84945208706OAI: diva2:867057

QC 20151104

Available from: 2015-11-04 Created: 2015-11-03 Last updated: 2015-11-04Bibliographically approved

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