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Absorption-dependent generation of singlet oxygen from gold bipyramids excited under low power density
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2015 (English)In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 5, no 100, 81897-81904 p.Article in journal (Refereed) Published
Abstract [en]

Metal nanoparticles (MNPs) can be used as a kind of new photodynamic therapy (PDT) agent because singlet oxygen (O-1(2)) can be generated through directly sensitizing MNPs. Gold nanorods, gold nanoshells and gold nanoechinus were confirmed to be efficient PDT agents in vivo. However, the major excitation spectra of O-1(2) from all of them are not in the optical biological window (650-900 nm). Herein, gold bipyramids (GBPs) with tunable absorption wavelength were prepared and used to explore O-1(2) generation capability. O-1(2) can be generated when GBPs were excited by continuous-wave light within a wide range of wavelengths (660-975 nm). The highest O-1(2) generation capabilities were obtained when they were excited at the wavelength of the absorption peak, which was quite different from those of other gold nanomaterials. It was also found that O-1(2) can be generated efficiently by a laser of very low power density (200 mW cm(-2)). The capability of GBPs for PDT has been demonstrated through the destruction of cancer cells. The synergistic effect of PDT and photothermal therapy for the destruction of cancer cells was also demonstrated.

Place, publisher, year, edition, pages
[Lv, Junliang; Zhang, Xin; Li, Nana; Wang, Baoju; He, Sailing] S China Normal Univ, S China Acad Adv Optoelect, SCNU ZJU Joint Res Ctr Photon, Ctr Opt & Electromagnet Res, Guangzhou 510006, Guangdong, Peoples R China. [He, Sailing] Royal Inst Technol, Dept Electromagnet Engn, S-10044 Stockholm, Sweden., 2015. Vol. 5, no 100, 81897-81904 p.
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Chemical Sciences
URN: urn:nbn:se:kth:diva-176387DOI: 10.1039/c5ra15362jISI: 000362437900016ScopusID: 2-s2.0-84942904503OAI: diva2:867471

QC 20151105

Available from: 2015-11-05 Created: 2015-11-03 Last updated: 2015-11-05Bibliographically approved

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