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Long-range recruitment of Martinotti cells causes surround suppression and promotes saliency in an attractor network model
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB. Stockholm University, Sweden.
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB. Stockholm University, Sweden.
2015 (English)In: Frontiers in Neural Circuits, ISSN 1662-5110, E-ISSN 1662-5110, Vol. 9, 60Article in journal (Refereed) Published
Abstract [en]

Although the importance of long-range connections for cortical information processing has been acknowledged for a long time, most studies focused on the long-range interactions between excitatory cortical neurons. Inhibitory interneurons play an important role in cortical computation and have thus far been studied mainly with respect to their local synaptic interactions within the cortical microcircuitry. A recent study showed that long-range excitatory connections onto Martinotti cells (MC) mediate surround suppression. Here we have extended our previously reported attractor network of pyramidal cells (PC) and MC by introducing long-range connections targeting MC. We have demonstrated how the network with Martinotti cell-mediated long-range inhibition gives rise to surround suppression and also promotes saliency of locations at which simple non-uniformities in the stimulus field are introduced. Furthermore, our analysis suggests that the presynaptic dynamics of MC is only ancillary to its orientation tuning property in enabling the network with saliency detection. Lastly, we have also implemented a disinhibitory pathway mediated by another interneuron type (VIP interneurons), which inhibits MC and abolishes surround suppression.

Place, publisher, year, edition, pages
[Krishnamurthy, Pradeep; Lansner, Anders] Stockholm Univ, Dept Numer Anal & Comp Sci, S-11428 Stockholm, Sweden. [Krishnamurthy, Pradeep; Lansner, Anders] Royal Inst Technol KTH, Sch Comp Sci & Commun, Dept Computat Biol, Stockholm, Sweden. [Silberberg, Gilad] Karolinska Inst, Dept Neurosci, Stockholm, Sweden., 2015. Vol. 9, 60
Keyword [en]
Martinotti cells, attractor network, disinhibition, inhibitory interneurons, long-range inhibition
National Category
Bioinformatics (Computational Biology) Neurosciences
URN: urn:nbn:se:kth:diva-176335DOI: 10.3389/fncir.2015.00060ISI: 000362837400001ScopusID: 2-s2.0-84944459981OAI: diva2:868041

QC 20151109

Available from: 2015-11-09 Created: 2015-11-03 Last updated: 2015-11-09Bibliographically approved

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