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HIV-1 antiviral behavior of anionic PPI metallo-dendrimers with EDA core
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2015 (English)In: European Journal of Medicinal Chemistry, ISSN 0223-5234, E-ISSN 1768-3254, Vol. 98, 139-148 p.Article in journal (Refereed) Published
Abstract [en]

The development of novel strategies to prevent HIV-1 infection is of outstanding relevance. Metal complexes of Cu2+, Ni2+, Co2+ and Zn2+ derived from sulfonated and carboxylated poly(propylene imine) dendrimers with ethylenediamine core were evaluated as tunable antiviral agents against HIV-1. After demonstrating their biocompatibility, specific trends in the antiviral properties were found, related to both the dendritic scaffold (peripheral group, generation) and the bound metal ions (sort, amount). In HEC-1A and VK-2 cell lines, as model of the first barrier against HIV-1 infection, a high preventive inhibitory action was found, which also avoided virus internalization inside cells and inhibited both CCR5 and CXCR4 HIV-1 strains. In peripheral blood mononuclear cells (PBMC), as model of the second barrier, a dual preventive and therapeutic behavior was observed. A rational design of such metallodendrimers opens new avenues for the production of versatile and efficient treatments against HIV-1 infection.

Place, publisher, year, edition, pages
2015. Vol. 98, 139-148 p.
Keyword [en]
Carboxylate, Dendrimer, HIV, Sulfonate, Transition metal, anti human immunodeficiency virus agent, chemokine receptor CCR5, chemokine receptor CXCR4, cobalt complex, copper complex, enfuvirtide, ethylenediamine, galactosylceramide, nickel complex, plerixafor, poly(propyleneimine), polypropylene, suramin, tenofovir, unclassified drug, zinc complex, antiviral activity, Article, binding affinity, biocompatibility, carboxylation, complex formation, conformational transition, controlled study, female, human, human cell, Human immunodeficiency virus 1, Human immunodeficiency virus 1 infection, in vitro study, internalization, nonhuman, peripheral blood mononuclear cell, sulfonation, tropism, virus entry, virus inhibition, virus particle, virus strain
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Medicinal Chemistry
URN: urn:nbn:se:kth:diva-175032DOI: 10.1016/j.ejmech.2015.05.026ISI: 000357245700010ScopusID: 2-s2.0-84929990934OAI: diva2:876546

QC 20151204

Available from: 2015-12-04 Created: 2015-10-09 Last updated: 2015-12-04Bibliographically approved

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García-Gallego, Sandra
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