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Delay valving in capillary driven devices based on dissolvable thin films
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-9552-4234
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
2014 (English)In: 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, Chemical and Biological Microsystems Society , 2014, p. 216-218Conference paper, Published paper (Refereed)
Abstract [en]

This work presents passive time delay valves for micro channels in two different working modes for microfluidic on chip timing. The delay valve designs are compatible with conventional lamination techniques for microfluidics and allow to pre-program advanced sequential operations independent from the geometries of the microfluidic system. The time delay of the dissolvable valves ranges from 1.2 s up to 36 s per valve resulting in a time range from 1.2 seconds up to 11 minutes for 19 serial valves.

Place, publisher, year, edition, pages
Chemical and Biological Microsystems Society , 2014. p. 216-218
Keywords [en]
Design, Laminating, Time delay, Micro fluidic system, On chips, Sequential operations, Time range, Valve design, Working mode, Microfluidics
National Category
Computer Engineering
Identifiers
URN: urn:nbn:se:kth:diva-174793Scopus ID: 2-s2.0-84931098273ISBN: 9780979806476 (print)OAI: oai:DiVA.org:kth-174793DiVA, id: diva2:878334
Conference
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, 26 October 2014 through 30 October 2014
Note

QC 20151208

Available from: 2015-12-08 Created: 2015-10-07 Last updated: 2018-09-11Bibliographically approved
In thesis
1. Capillary driven devices for patient-centric diagnostics
Open this publication in new window or tab >>Capillary driven devices for patient-centric diagnostics
2018 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Lateral flow assays is an example of a successful microfluidic platform relying on passive fluid transport, making them suitable for patient-centric and point-of-care applications. Flow control and valving in capillary driven devices typically rely on design-imprinted functions and operations which can be a limiting factor. This thesis explores dissolvable polymer valves in capillary driven microfluidic systems, a novel type of valves with a timing function. The dissolvable valve technology was used to develop autonomous operations in lamination-based polymer microfluidic systems such as sequential reagent delivery, reagent release and volume-metering, and further utilizes this technology in the Dried Blood Spot (DBS) and Dried Plasma Spot applications described below. Lamination technology is suitable for the integration of the water-dissolvable polymer layers and allows upscaling at a relatively low cost. Advances in the development of LC-MS/MS systems enable the quantification of analytes in microliter-sized blood samples such as DBS. This makes DBS sampling a minimally invasive alternative to venous blood sampling with logistical and ethical advantages for users and health care providers. Unknown sample volume, spot inhomogeneity and hematocrit-related issues have been an obstacle for a wider acceptance of DBS sampling technology. To address these issues, a novel blood-sampling device, the microfluidic DBS card, has been developed within this thesis. The device function is based on capillary driven volume-metering and allows accurate and user independent collection of microliter-sized DBS, directly from a finger-prick. The microfluidic DBS card could help to eliminate some of the issues related to DBS sampling and contribute to a wider acceptance of the technology. Usability and reliability have been considered during the development to enable testing of the microfludic DBS card in a pre-clinical setting. For many analytes and biomarkers, conventional blood sample analysis is performed on plasma or serum samples. This thesis further discusses the use of capillary driven plasma separation based on commercially available asymmetric filtration membranes and capillary driven flow in microchannels. A novel concept for hematocrit and input-volume-independent collection of a 11.6~µl plasma sample from a single drop of blood is demonstrated. The plasma sample is automatically transferred to a sample collection pad forming a Dried Plasma Spot. This could be the next generation of dried sample matrix, enabling an accurate quantification of analytes in Dried Plasma Spots.

Place, publisher, year, edition, pages
Stockholm: Kungliga Tekniska högskolan, 2018. p. 81
Series
TRITA-EECS-AVL ; 2018:58
Keywords
Capillary driven, Microfluidic, Dissolvable valves, PVA, Volume metering, Dried Blood Spots, DBS, Dried Plasma Spots, DPS
National Category
Medical Engineering
Research subject
Medical Technology
Identifiers
urn:nbn:se:kth:diva-234679 (URN)978-91-7729-919-6 (ISBN)
Public defence
2018-09-28, F3, Lindstedtsvägen 26, Stockholm, 10:00 (English)
Opponent
Supervisors
Note

QC 20180910

Available from: 2018-09-10 Created: 2018-09-07 Last updated: 2018-09-10Bibliographically approved

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Stemme, Göran

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