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Computational models of lamprey locomotor network neurons
KTH, School of Computer Science and Communication (CSC), Numerical Analysis and Computer Science, NADA.
2005 (English)Licentiate thesis, comprehensive summary (Other scientific)
Place, publisher, year, edition, pages
Stockholm: KTH , 2005. , 51 p.
Series
Trita-NA, ISSN 0348-2952 ; 0505
Keyword [en]
Datorsystem
Keyword [sv]
Datorsystem
National Category
Computer Engineering
Identifiers
URN: urn:nbn:se:kth:diva-304ISBN: 91-7283-971-6 (print)OAI: oai:DiVA.org:kth-304DiVA: diva2:8789
Presentation
2005-02-23, Sal D34, Lindstedtsvägen 5, Stockholm, 09:00
Supervisors
Note
QC 20101201Available from: 2005-07-15 Created: 2005-07-15 Last updated: 2010-12-01Bibliographically approved
List of papers
1. Role of A-current in lamprey locomotor network neurons
Open this publication in new window or tab >>Role of A-current in lamprey locomotor network neurons
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2003 (English)In: Neurocomputing, ISSN 0925-2312, E-ISSN 1872-8286, Vol. 52-54, 295-300 p.Article in journal (Refereed) Published
Abstract [en]

A compartmental model of lamprey central pattern generator neurons was built in order to examine the effects of a fast, transient, high-voltage-activated potassium current (A-current) found experimentally. The model consisted of a soma, a compartment corresponding to the axon initial segment, and a dendritic tree. The simulation showed that the A-current was necessary for repetitive spiking in the single neuron following current injection. The functional role of adding an A-current was also examined in a network model. In this model, the A-current stabilizes the swimming rhythm by making the burst cycle duration and the number of spikes per burst less variable. All these effects are also seen experimentally.

Keyword
A-current, lamprey, potassium, CPG, Hodgkin-Huxley
National Category
Computer Engineering
Identifiers
urn:nbn:se:kth:diva-22590 (URN)10.1016/s0925-2312(02)00784-1 (DOI)000183514300044 ()
Note
QC 20100525 QC 20111229Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2017-12-12Bibliographically approved
2. mGluR-mediated calcium oscillations in the lamprey: a computational model
Open this publication in new window or tab >>mGluR-mediated calcium oscillations in the lamprey: a computational model
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2004 (English)In: Neurocomputing, ISSN 0925-2312, Vol. 58-60, 431-435 p.Article in journal (Refereed) Published
Abstract [en]

Slow Ca2+ oscillations caused by release from intracellular stores have been observed in neurons in the lamprey spinal cord. These oscillations are triggered by activation of metabotropic glutamate receptors on the cell surface. The pathway leading from receptor activation to the inositol triphosphate-mediated release of Ca2+ from the endoplasmatic reticulum has been modelled in order to facilitate further understanding of the nature of these oscillations. The model generates Ca2+ oscillations with a frequency range of 0.01-0.09 Hz. A prediction of the model is that the frequency will increase with a stronger extracellular glutamate signal.

Keyword
Calcium oscillations; Lamprey; mGluR5; Spinal cord
National Category
Computer Science
Identifiers
urn:nbn:se:kth:diva-7267 (URN)10.1016/j.neucom.2004.01.077 (DOI)000222245900065 ()
Note
QC 20100715. Titel ändrad 20100715, tidigare titel: mGluR-dependent calcium oscillations in lamprey spinal cord neurons.Available from: 2007-06-01 Created: 2007-06-01 Last updated: 2011-10-27Bibliographically approved
3. Functional roles of ionic currents in lamprey CPG neurons: a model study
Open this publication in new window or tab >>Functional roles of ionic currents in lamprey CPG neurons: a model study
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(English)Manuscript (preprint) (Other academic)
National Category
Computer Engineering
Identifiers
urn:nbn:se:kth:diva-26987 (URN)
Note

QC 20101201

Available from: 2010-12-01 Created: 2010-12-01 Last updated: 2015-09-15Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf