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Glyconanomaterials for Combating Bacterial Infections
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
2015 (English)In: Chemistry A., ISSN 0947-6539, Vol. 21, no 46, 16310-16317 p.Article in journal (Refereed) Published
Abstract [en]

Bacterial infections constitute an increasing problem to human health in response to build-up of resistance to present antibiotics and sluggish development of new pharmaceuticals. However, a means to address this problem is to pinpoint the drug delivery to-and into-the bacteria. This results in a high local concentration of the drug, circumventing the increasingly high doses otherwise necessary. Combined with other effectors, such as covalent attachment to carriers, rendering the drugs less degradable, and the combination with efflux inhibitors, old drugs can be revived. In this context, glyconanomaterials offer exceptional potential, since these materials can be tailored to accommodate different effectors. In this Concept article, we describe the different advantages of glyconanomaterials, and point to their potential in antibiotic "revitalization".

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2015. Vol. 21, no 46, 16310-16317 p.
Keyword [en]
Antibiotics, Carbohydrates, Materials Science, Nanostructures, Supramolecular Chemistry
National Category
Infectious Medicine
URN: urn:nbn:se:kth:diva-176945DOI: 10.1002/chem.201502842ISI: 000365132100004PubMedID: 26418195ScopusID: 2-s2.0-84945975053OAI: diva2:882326

QC 20151214

Available from: 2015-12-14 Created: 2015-11-13 Last updated: 2015-12-18Bibliographically approved

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