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FemHab: Prooxidant/antioxidant balance during and following a 10-day hypoxic bed rest
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
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2015 (English)Conference paper (Refereed)
Abstract [en]

Introduction:Inhabitants of the envisaged planetary habitats will be continuously exposed to reduced gravity and hypoxia. The combined effects of unloading and hypoxia on prooxidant/antioxidant balance are currently unknown.

Methods:Healthy female participants underwent the following three, 10-day interventions: i) Normobaric normoxic bed-rest (NBR; n=11; FiO2=0.209) ii) Normobaric hypoxic ambulatory confinement (HAMB; n=9: FiO2~0.141), and iii) Normobaric hypoxic bed-rest (HBR; n=12; FiO2~0.141). Plasma oxidative stress [advanced oxidation protein products (AOPP) and nitrotyrosine], antioxidant markers [superoxide dismutase (SOD) and glutathione peroxidase (GPX)] and nitrites were determined before (Pre), during (Day 2, Day 6), immediately after (Post) and 24-hrs after (Post+1) each campaign.

Results:Compared to Pre, the AOPP was only higher on Day 2, Day 6 and Post during the HBR and at Post during the NBR (P<0.05) while the nitrotyrosine was significantly reduced at Post+1 only during the HAMB (P<0.05). Higher levels of SOD were observed during the HAMB at Day 6 and Post+1whereas GPX was reduced at Day 6 and Post during the HBR. Nitrites were significantly higher at Post+1 in the HAMB both, compared to Pre and compared to HBR and NBR (P<0.05).

Conclusion:These data suggest that the unloading-induced oxidative stress is exacerbated by exposure to simulated altitude of ~4000m. In addition, even habitual (low) physical activity, performed during hypoxic exposure, seems to blunt hypoxia-related oxidative stress via antioxidant system upregulation.

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URN: urn:nbn:se:kth:diva-179351ISBN: 978-961-93848-0-0OAI: diva2:882665
The 36th Annual International Gravitational Physiology Meeting, Ljubljana, Slovenia

QC 20161021

Available from: 2015-12-15 Created: 2015-12-15 Last updated: 2016-01-21Bibliographically approved

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Eiken, Ola
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Environmental PhysiologySwedish Aerospace Physiology Centre, SAPC

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