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Regulation of cardiac output in hypoxia.
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
2015 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 25, no Suppl 4, 53-59 p.Article in journal (Refereed) Published
Abstract [en]

This brief review addresses the regulation of cardiac output (Q) at rest and during submaximal exercise in acute and chronic hypoxia. To preserve systemic O-2 delivery in acute hypoxia Q is increased by an acceleration of heart rate, whereas stroke volume (SV) remains unchanged. Tachycardia is governed by activation of carotid and aortic chemoreceptors and a concomitant reduction in arterial baroreflex activation, all balancing sympathovagal activity toward sympathetic dominance. As hypoxia extends over several days a combination of different adaptive processes restores arterial O-2 content to or beyond sea level values and hence Q normalizes. The latter however occurs as a consequence of a decrease in SV whereas tachycardia persists. The diminished SV reflects a lower left ventricular end-diastolic volume which is primarily related to hypoxia-generated reduction in plasma volume. Hypoxic pulmonary vasoconstriction may contribute by increasing right ventricular afterload and thus decreasing its ejection fraction. In summary, the Q response to hypoxia is the result of a complex interplay between several physiological mechanisms. Future studies are encouraged to establish the individual contributions of the different components from an integrative perspective.

Place, publisher, year, edition, pages
Blackwell Munksgaard, 2015. Vol. 25, no Suppl 4, 53-59 p.
Keyword [en]
Chemoreflex, Exercise, Hypoxemia, Para-sympathetic, Rest, Vagal
National Category
URN: urn:nbn:se:kth:diva-179381DOI: 10.1111/sms.12619ISI: 000365322300015PubMedID: 26589118ScopusID: 2-s2.0-84948414608OAI: diva2:882768

QC 20160112

Available from: 2015-12-15 Created: 2015-12-15 Last updated: 2016-01-12Bibliographically approved

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Siebenmann, Christoph
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Environmental Physiology
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