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Visual assessment of biliary excretion of Gd-EOB-DTPA in patients with suspected diffuse liver disease–A biopsy-verified prospective study
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2015 (English)In: European Journal of Radiology Open, Vol. 2, 19-25 p.Article in journal (Refereed) PublishedText
Abstract [en]

Objectives

To qualitatively evaluate late dynamic contrast phases, 10, 20 and 30 min, after administration of Gd-EOB-DTPA with regard to biliary excretion in patients presenting with elevated liver enzymes without clinical signs of cirrhosis or hepatic decompensation and to compare the visual assessment of contrast agent excretion with histo-pathological fibrosis stage, contrast uptake parameters and blood tests.

Methods

29 patients were prospectively examined using 1.5 T MRI. The visually assessed presence or absence of contrast agent for each of five anatomical regions in randomly reviewed time-series was summarized on a four grade scale for each patient. The scores, including a total visual score, were related to the histo-pathological findings, the quantitative contrast agent uptake parameters, expressed as KHep or LSC_N, and blood tests.

Results

No relationship between the fibrosis grade or contrast uptake parameters could be established. A negative correlation between the visual assessment and alkaline phosphatase (ALP) was found. Comparing a sub-group of cholestatic patients with fibrosis score and Gd-EOB-DTPA dynamic parameters did not add any additional significant correlation.

Conclusions

No correlation between visually assessed biliary excretion of Gd-EOB-DTPA and histo-pathological or contrast uptake parameters was found. A negative correlation between the visual assessment and alkaline phosphatase (ALP) was found.

Place, publisher, year, edition, pages
2015. Vol. 2, 19-25 p.
National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
Medical Technology
Identifiers
URN: urn:nbn:se:kth:diva-179949DOI: 10.1016/j.ejro.2014.12.004ScopusID: 2-s2.0-84923936531OAI: oai:DiVA.org:kth-179949DiVA: diva2:890874
Note

QC 20160112. QC 20160113

Available from: 2016-01-05 Created: 2016-01-05 Last updated: 2016-02-05Bibliographically approved

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Smedby, Örjan
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Medical Image Processing and Visualization
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