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Patient-specific flow simulation of the left ventricle from 4D echocardiography - feasibility and robustness evaluation
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.ORCID iD: 0000-0003-1002-2070
KTH, School of Computer Science and Communication (CSC), High Performance Computing and Visualization (HPCViz).
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.ORCID iD: 0000-0002-9090-9028
KTH, School of Computer Science and Communication (CSC), High Performance Computing and Visualization (HPCViz).ORCID iD: 0000-0003-4256-0463
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2015 (English)In: 2015 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), IEEE , 2015Conference paper (Refereed)Text
Abstract [en]

In recent years, computational fluid dynamics (CFD) simulations on in-silico models of the heart have provided a valuable insight into cardiac hemodynamic behaviour. However, so far most models have been either based on simplified geometries or on imaging acquisitions with relatively low temporal resolution. It has been suggested that models based entirely on subject-specific ultrasonic images should be used to capture transient flow changes. Therefore, the aim of this study is to present a pathway from routine 4D echocardiography to a patient-specific flow simulation of the left ventricle (LV), evaluating the model robustness and clinical feasibility. The created pathway consisted of initial LV segmentation and mitral/aortic valve positioning, being subsequently used as input for the CFD simulations (based on solving the Navier-Stokes equation using an Arbitrary Lagrangian-Eulerian approach). The output consisted of 4D blood flow velocities and relative pressures in the entire LV. On five subjects, the model robustness was evaluated with regards to variations in singular boundary conditions. The clinical feasibility of the output was compared to clinical PW Doppler measurements and, as a proof-of-concept, synthetic contrast enhanced ultrasound images were simulated on the flow field using the COLE-method. Results indicated a relatively robust model, with variations in regional flow of approximately 5.1/6.2% and 9.7/7.0% for healthy and pathological subject respectively (end diastole/end systole). Furthermore, showing similar behaviour to clinical Doppler measurements the technique serves as a promising tool for future clinical investigations. Additionally, the ability of simulating synthetic ultrasound images further underlines the applicability of the pathway, being potentially useful in studies on improved echocardiographic image analysis.

Place, publisher, year, edition, pages
IEEE , 2015.
Series
, IEEE International Ultrasonics Symposium, ISSN 1948-5719
Keyword [en]
Patient-specific, Flow simulation, Ultrasound simulation, 4D Echocardiography, Computational Fluid Dynamics
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-180168DOI: 10.1109/ULTSYM.2015.0233ISI: 000366045700279ScopusID: 2-s2.0-84961989695ISBN: 978-1-4799-8182-3OAI: oai:DiVA.org:kth-180168DiVA: diva2:893144
Conference
IEEE International Ultrasonics Symposium (IUS), OCT 21-24, 2015, Taipei, TAIWAN
Note

QC 20160112

Available from: 2016-01-12 Created: 2016-01-07 Last updated: 2016-01-14Bibliographically approved

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Larsson, DavidSpuhler, Jeannette H.Nordenfur, TimHoffman, JohanColarieti-Tosti, MassimilianoLarsson, Matilda
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