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Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab. Chalmers University of Technology, Sweden.
2015 (English)In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 6, 342Article, review/survey (Refereed) PublishedText
Abstract [en]

To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labeled with stable isotopes and mathematical modeling, provides us with a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering our understanding of the pathogenesis of dyslipoproteinemia.

Place, publisher, year, edition, pages
Frontiers Research Foundation , 2015. Vol. 6, 342
Keyword [en]
very low density lipoproteins, apoB, multocomnpartmental modeling, kinetics, stable isotopes
National Category
Physiology
Identifiers
URN: urn:nbn:se:kth:diva-180514DOI: 10.3389/fphys.2015.00342ISI: 000366746900001ScopusID: 2-s2.0-84949673329OAI: oai:DiVA.org:kth-180514DiVA: diva2:894480
Note

QC 20160115

Available from: 2016-01-15 Created: 2016-01-14 Last updated: 2016-01-15Bibliographically approved

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