Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans
2015 (English)In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 6, 342Article, review/survey (Refereed) PublishedText
To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labeled with stable isotopes and mathematical modeling, provides us with a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering our understanding of the pathogenesis of dyslipoproteinemia.
Place, publisher, year, edition, pages
Frontiers Research Foundation , 2015. Vol. 6, 342
very low density lipoproteins, apoB, multocomnpartmental modeling, kinetics, stable isotopes
IdentifiersURN: urn:nbn:se:kth:diva-180514DOI: 10.3389/fphys.2015.00342ISI: 000366746900001ScopusID: 2-s2.0-84949673329OAI: oai:DiVA.org:kth-180514DiVA: diva2:894480
QC 201601152016-01-152016-01-142016-01-15Bibliographically approved