In-Vitro Study of the Material Properties of Polyurethane Catheters from Subcutaneous Venous Access Ports Exposed to Simulated Chemotherapy Treatment
Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
Bestämning av materialegenskaper hos SVAP polyuretankatetrar efter exponering för simulerad kemoterapibehandling i en in-vitro studie (Swedish)
Central Venous Catheters (CVCs) are used to provide safe administration of chemotherapeutic drugsduring breast cancer treatment. This study focused on how the exposure of the medical drugs influences the material properties providing possible alterations of the inner surface of one type of CVCs,the Subcutaneous Venous Access Port (SVAP).The SVAP is completely implanted under the skin and is associated with fewer complications and restrictions in regards to physical activity for the patient compared to other eves on the market.
The polyurethane catheters from the SVAP examined in this study were obtained from a previous study. The samples were exposed to chemotherapy treatments, containing the cytostatic drugs FE100C + Taxotere, following the treatment protocol for patients, over a prolonged period of time, i.e. 18 weeks. One reference sample exposed to NaCl solution according to the same procedure was obtained from another study conducted earlier.
The surface degradation on the inner catheter surface was analyzed by the Field Emission Scanning Electron Microscopy (FE-SEM). An increase in porosity and crazing of the material were observed throughout the duration of the treatment. This is caused by the leaching of additives/particlesfrom the material, resulting in alteration of the mechanical and chemical properties.
The effect on the mechanical properties was analyzed by tensile test. After exposure to chemotherapy treatment a decrease in strength and increase in ductility of the material were observed. The uncertainty in the characterization method of the dynamic contact anglemeasurements made it difficult to conclude a prominent trend for the changes in hydrophobicityofthe material. The analysis, however, indicated that exposure to chemotherapy treatment affectedthe surfaceroughness.
The results in this study clearly indicate the degradation of the polyurethane catheters afterlongterm exposure to chemotherapy drugs,however,further research is required to estimate the extent of the material deterioration.
Place, publisher, year, edition, pages
CVC, Polyurethane catheters, chemotherapy, mechanical properties, morphology
Engineering and Technology
IdentifiersURN: urn:nbn:se:kth:diva-180546OAI: oai:DiVA.org:kth-180546DiVA: diva2:895264