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Exploring water as building bricks in enzyme engineering
KTH, School of Biotechnology (BIO), Industrial Biotechnology.
KTH, School of Biotechnology (BIO), Industrial Biotechnology.ORCID iD: 0000-0002-2993-9375
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.ORCID iD: 0000-0002-4066-2776
2015 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 51, no 97, 17221-17224 p.Article in journal (Refereed) PublishedText
Abstract [en]

A novel enzyme engineering strategy for accelerated catalysis based on redesigning a water network through protein backbone deshielding is presented. Fundamental insight into the energetic consequences associated with the design is discussed in the light of experimental results and computer simulations. Using water as biobricks provides unique opportunities when transition state stabilisation is not easily attained by traditional enzyme engineering.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2015. Vol. 51, no 97, 17221-17224 p.
National Category
Industrial Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-180600DOI: 10.1039/c5cc07162cISI: 000366954800004PubMedID: 26426706ScopusID: 2-s2.0-84948408732OAI: oai:DiVA.org:kth-180600DiVA: diva2:896177
Funder
Swedish Research Council, 621-2013-5138
Note

QC 20160120

Available from: 2016-01-20 Created: 2016-01-19 Last updated: 2016-02-11Bibliographically approved

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