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Immunocapture strategies in translational proteomics
KTH, School of Biotechnology (BIO). KTH, Centres, Science for Life Laboratory, SciLifeLab.
KTH, School of Biotechnology (BIO). KTH, Centres, Science for Life Laboratory, SciLifeLab.
KTH, School of Biotechnology (BIO). KTH, Centres, Science for Life Laboratory, SciLifeLab.
KTH, School of Biotechnology (BIO). KTH, Centres, Science for Life Laboratory, SciLifeLab.
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2016 (English)In: Expert Review of Proteomics, ISSN 1478-9450, E-ISSN 1744-8387, Vol. 13, no 1, 83-98 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Aiming at clinical studies of human diseases, antibody-assisted assays have been applied to biomarker discovery and toward a streamlined translation from patient profiling to assays supporting personalized treatments. In recent years, integrated strategies to couple and combine antibodies with mass spectrometry-based proteomic efforts have emerged, allowing for novel possibilities in basic and clinical research. Described in this review are some of the field's current and emerging immunocapture approaches from an affinity proteomics perspective. Discussed are some of their advantages, pitfalls and opportunities for the next phase in clinical and translational proteomics.

Place, publisher, year, edition, pages
Taylor & Francis, 2016. Vol. 13, no 1, 83-98 p.
Keyword [en]
Antibodies, immunocapture, mass spectrometry, protein enrichment, sandwich assays, SRM
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-180965DOI: 10.1586/14789450.2016.1111141ISI: 000367351000001PubMedID: 26558424OAI: oai:DiVA.org:kth-180965DiVA: diva2:898633
Note

QC 20160128

Available from: 2016-01-28 Created: 2016-01-26 Last updated: 2016-01-28Bibliographically approved

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Fredolini, ClaudiaByström, SannaPin, ElisaEdfors, FredrikIglesias, Maria JesusHäggmark, AnnaHong, Mun-GwanUhlén, MathiasNilsson, PeterSchwenk, Jochen M.
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School of Biotechnology (BIO)Science for Life Laboratory, SciLifeLab
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Expert Review of Proteomics
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