Immunocapture strategies in translational proteomics
2016 (English)In: Expert Review of Proteomics, ISSN 1478-9450, E-ISSN 1744-8387, Vol. 13, no 1, 83-98 p.Article, review/survey (Refereed) PublishedText
Aiming at clinical studies of human diseases, antibody-assisted assays have been applied to biomarker discovery and toward a streamlined translation from patient profiling to assays supporting personalized treatments. In recent years, integrated strategies to couple and combine antibodies with mass spectrometry-based proteomic efforts have emerged, allowing for novel possibilities in basic and clinical research. Described in this review are some of the field's current and emerging immunocapture approaches from an affinity proteomics perspective. Discussed are some of their advantages, pitfalls and opportunities for the next phase in clinical and translational proteomics.
Place, publisher, year, edition, pages
Taylor & Francis, 2016. Vol. 13, no 1, 83-98 p.
Antibodies, immunocapture, mass spectrometry, protein enrichment, sandwich assays, SRM
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:kth:diva-180965DOI: 10.1586/14789450.2016.1111141ISI: 000367351000001PubMedID: 26558424OAI: oai:DiVA.org:kth-180965DiVA: diva2:898633
QC 201601282016-01-282016-01-262016-01-28Bibliographically approved