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ARTERIAL STIFFNESS ESTIMATION BY SHEAR WAVE ELASTOGRAPHY: VALIDATION IN PHANTOMS WITH MECHANICAL TESTING
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging. Karolinska Institutet, Sweden.ORCID iD: 0000-0002-9654-447X
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging. Karolinska Institutet, Sweden.ORCID iD: 0000-0002-2487-7400
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.ORCID iD: 0000-0003-1002-2070
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2016 (English)In: Ultrasound in Medicine and Biology, ISSN 0301-5629, E-ISSN 1879-291X, Vol. 42, no 1, 308-321 p.Article in journal (Refereed) PublishedText
Abstract [en]

Arterial stiffness is an independent risk factor found to correlate with a wide range of cardiovascular diseases. It has been suggested that shear wave elastography (SWE) can be used to quantitatively measure local arterial shear modulus, but an accuracy assessment of the technique for arterial applications has not yet been performed. In this study, the influence of confined geometry on shear modulus estimation, by both group and phase velocity analysis, was assessed, and the accuracy of SWE in comparison with mechanical testing was measured in nine pressurized arterial phantoms. The results indicated that group velocity with an infinite medium assumption estimated shear modulus values incorrectly in comparison with mechanical testing in arterial phantoms (6.7 +/- 0.0 kPa from group velocity and 30.5 +/- 0.4 kPa from mechanical testing). To the contrary, SWE measurements based on phase velocity analysis (30.6 +/- 3.2 kPa) were in good agreement with mechanical testing, with a relative error between the two techniques of 8.8 +/- 6.0% in the shear modulus range evaluated (40-100 kPa). SWE by phase velocity analysis was validated to accurately measure stiffness in arterial phantoms.

Place, publisher, year, edition, pages
2016. Vol. 42, no 1, 308-321 p.
Keyword [en]
Accuracy, Arterial phantom, Arterial stiffness, Group velocity, Lamb waves, Mechanical testing, Phase velocity, Poly(vinyl alcohol), Shear modulus, Shear wave elastography
National Category
Medical Image Processing
Identifiers
URN: urn:nbn:se:kth:diva-181377DOI: 10.1016/j.ultrasmedbio.2015.08.012ISI: 000367733800032PubMedID: 26454623ScopusID: 2-s2.0-84957007046OAI: oai:DiVA.org:kth-181377DiVA: diva2:900298
Funder
VINNOVA, 2011-01365Swedish Research Council, 2012-2795
Note

QC 20160203

Available from: 2016-02-03 Created: 2016-02-01 Last updated: 2016-02-03Bibliographically approved

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Maksuti, EliraWidman, ErikLarsson, DavidLarsson, MatildaBjällmark, Anna
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