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ARTERIAL STIFFNESS ESTIMATION BY SHEAR WAVE ELASTOGRAPHY: VALIDATION IN PHANTOMS WITH MECHANICAL TESTING
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging. Karolinska Institutet, Sweden.ORCID iD: 0000-0002-9654-447X
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging. Karolinska Institutet, Sweden.ORCID iD: 0000-0002-2487-7400
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.ORCID iD: 0000-0003-1002-2070
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2016 (English)In: Ultrasound in Medicine and Biology, ISSN 0301-5629, E-ISSN 1879-291X, Vol. 42, no 1, 308-321 p.Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

Arterial stiffness is an independent risk factor found to correlate with a wide range of cardiovascular diseases. It has been suggested that shear wave elastography (SWE) can be used to quantitatively measure local arterial shear modulus, but an accuracy assessment of the technique for arterial applications has not yet been performed. In this study, the influence of confined geometry on shear modulus estimation, by both group and phase velocity analysis, was assessed, and the accuracy of SWE in comparison with mechanical testing was measured in nine pressurized arterial phantoms. The results indicated that group velocity with an infinite medium assumption estimated shear modulus values incorrectly in comparison with mechanical testing in arterial phantoms (6.7 +/- 0.0 kPa from group velocity and 30.5 +/- 0.4 kPa from mechanical testing). To the contrary, SWE measurements based on phase velocity analysis (30.6 +/- 3.2 kPa) were in good agreement with mechanical testing, with a relative error between the two techniques of 8.8 +/- 6.0% in the shear modulus range evaluated (40-100 kPa). SWE by phase velocity analysis was validated to accurately measure stiffness in arterial phantoms.

Place, publisher, year, edition, pages
2016. Vol. 42, no 1, 308-321 p.
Keyword [en]
Accuracy, Arterial phantom, Arterial stiffness, Group velocity, Lamb waves, Mechanical testing, Phase velocity, Poly(vinyl alcohol), Shear modulus, Shear wave elastography
National Category
Medical Image Processing
Identifiers
URN: urn:nbn:se:kth:diva-181377DOI: 10.1016/j.ultrasmedbio.2015.08.012ISI: 000367733800032PubMedID: 26454623Scopus ID: 2-s2.0-84957007046OAI: oai:DiVA.org:kth-181377DiVA: diva2:900298
Funder
VINNOVA, 2011-01365Swedish Research Council, 2012-2795
Note

QC 20160203

Available from: 2016-02-03 Created: 2016-02-01 Last updated: 2016-11-15Bibliographically approved
In thesis
1. Imaging and modeling the cardiovascular system
Open this publication in new window or tab >>Imaging and modeling the cardiovascular system
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Understanding cardiac pumping function is crucial to guiding diagnosis, predicting outcomes of interventions, and designing medical devices that interact with the cardiovascular system.  Computer simulations of hemodynamics can show how the complex cardiovascular system is influenced by changes in single or multiple parameters and can be used to test clinical hypotheses. In addition, methods for the quantification of important markers such as elevated arterial stiffness would help reduce the morbidity and mortality related to cardiovascular disease.

The general aim of this thesis work was to improve understanding of cardiovascular physiology and develop new methods for assisting clinicians during diagnosis and follow-up of treatment in cardiovascular disease. Both computer simulations and medical imaging were used to reach this goal.

In the first study, a cardiac model based on piston-like motions of the atrioventricular plane was developed. In the second study, the presence of the anatomical basis needed to generate hydraulic forces during diastole was assessed in heathy volunteers. In the third study, a previously validated lumped-parameter model was used to quantify the contribution of arterial and cardiac changes to blood pressure during aging. In the fourth study, in-house software that measures arterial stiffness by ultrasound shear wave elastography (SWE) was developed and validated against mechanical testing.

The studies showed that longitudinal movements of the atrioventricular plane can well explain cardiac pumping and that the macroscopic geometry of the heart enables the generation of hydraulic forces that aid ventricular filling. Additionally, simulations showed that structural changes in both the heart and the arterial system contribute to the progression of blood pressure with age. Finally, the SWE technique was validated to accurately measure stiffness in arterial phantoms.

Place, publisher, year, edition, pages
KTH Royal Institute of Technology, 2016. 96 p.
Series
TRITA-STH, 2016:9
Keyword
Cardiac pumping, diastolic function, hemodynamics, modeling, simulation, arterial stiffness, ultrasound, shear wave elastography.
National Category
Other Medical Engineering
Research subject
Medical Technology
Identifiers
urn:nbn:se:kth:diva-196538 (URN)978-91-7729-192-3 (ISBN)
Public defence
2016-12-09, T2, Hälsovägen 11C, Huddinge, 10:00 (English)
Opponent
Supervisors
Funder
Swedish Research Council, 2012-2800, 2012-2795VINNOVA, 2011-01365
Note

QC 20161115

Available from: 2016-11-15 Created: 2016-11-15 Last updated: 2016-11-15Bibliographically approved

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