Na+, K+-ATPase, a new class of plasma membrane receptors
2016 (English)In: American Journal of Physiology - Cell Physiology, ISSN 0363-6143, E-ISSN 1522-1563, Vol. 310, no 7, C491-C495 p.Article in journal (Refereed) Published
The Na(+), K(+)-ATPase (NKA) differs from most other ion transporters not only in its capacity to maintain a steep electrochemical gradient across the plasma membrane but also as a receptor for a family of cardiotonic steroids, to which ouabain belongs. Studies from many groups, performed during the last fifteen years, have demonstrated that ouabain, a member of the cardiotonic steroid family, can activate a network of signaling molecules and that NKA will also serve as a signal transducer that can provide a feed back loop between NKA and the mitochondria. This brief review summarizes the current knowledge and controversies with regard to the understanding of NKA signaling.
Place, publisher, year, edition, pages
American Physiological Society , 2016. Vol. 310, no 7, C491-C495 p.
Other Physics Topics Biological Sciences
IdentifiersURN: urn:nbn:se:kth:diva-182106DOI: 10.1152/ajpcell.00359.2015ISI: 000373273900001PubMedID: 26791490OAI: oai:DiVA.org:kth-182106DiVA: diva2:903287
QC 201604252016-02-152016-02-152016-04-25Bibliographically approved