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Na+, K+-ATPase, a new class of plasma membrane receptors
KTH, School of Engineering Sciences (SCI), Applied Physics, Cell Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics, Cell Physics.ORCID iD: 0000-0003-0578-4003
2016 (English)In: American Journal of Physiology - Cell Physiology, ISSN 0363-6143, E-ISSN 1522-1563, Vol. 310, no 7, p. C491-C495Article in journal (Refereed) Published
Abstract [en]

The Na(+), K(+)-ATPase (NKA) differs from most other ion transporters not only in its capacity to maintain a steep electrochemical gradient across the plasma membrane but also as a receptor for a family of cardiotonic steroids, to which ouabain belongs. Studies from many groups, performed during the last fifteen years, have demonstrated that ouabain, a member of the cardiotonic steroid family, can activate a network of signaling molecules and that NKA will also serve as a signal transducer that can provide a feed back loop between NKA and the mitochondria. This brief review summarizes the current knowledge and controversies with regard to the understanding of NKA signaling.

Place, publisher, year, edition, pages
American Physiological Society , 2016. Vol. 310, no 7, p. C491-C495
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Other Physics Topics Biological Sciences
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URN: urn:nbn:se:kth:diva-182106DOI: 10.1152/ajpcell.00359.2015ISI: 000373273900001PubMedID: 26791490OAI: oai:DiVA.org:kth-182106DiVA, id: diva2:903287
Note

QC 20160425

Available from: 2016-02-15 Created: 2016-02-15 Last updated: 2017-11-30Bibliographically approved

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Brismar, Hjalmar

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