Morphology Tuning of Self-Assembled Perylene. Monoimide from Nanoparticles to Colloidosomes with Enhanced Excimeric NIR Emission for Bioimaging
2016 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 8, no 3, 2336-2347 p.Article in journal (Refereed) PublishedText
Organic near-infrared (NIR) fluorescent probes have been recognized as an emerging class of materials exhibiting a great potential in advanced bioanalytical applications. However, synthesizing such organic probes that could simultaneously work in the NIR spectral range and have large Stokes shift, high stability in biological systems, and high photostability have been proven challenging. In this work, aggregation induced excimeric NIR emission in aqueous media was observed from a suitably substituted perylene monoimide (PeIm) dye. Controlled entrapment of the dye into pluronic F127 micellar system to preserve its monomeric green emission in aqueous media was also established. The aggregation process of the PeIm dye to form organic nanoparticles (NPs) was evaluated experimentally by the means of transmission electron microscope imaging as well as theoretically by the molecular dynamics simulation studies. Tuning the morphology along with the formation of colloidosomes by the controlled self-aggregation of PeIm NPs in aqueous suspension was demonstrated successfully. Finally, both excimeric and monomeric emissive PeIm NPs as well as PeIm colloidosomes were employed for the bioimaging in vitro.
Place, publisher, year, edition, pages
American Chemical Society (ACS), 2016. Vol. 8, no 3, 2336-2347 p.
colloidosomes, morphology tuning, NIR emission, organic nanoparticles, self-assembly
Materials Engineering Chemical Sciences
IdentifiersURN: urn:nbn:se:kth:diva-182782DOI: 10.1021/acsami.5b11411ISI: 000369044100094PubMedID: 26728416ScopusID: 2-s2.0-84955617862OAI: oai:DiVA.org:kth-182782DiVA: diva2:906022
QC 201602232016-02-232016-02-232016-02-23Bibliographically approved