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Cardiovascular disease and mortality after a first episode of venous thromboembolism in young and middle-aged women
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab. Karolinska University Hospital, Sweden.
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2016 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 138, 80-85 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background: Patients with a history of venous thromboembolism (VTE) seem to have an increased risk of arterial cardiovascular disease (CVD). Objectives: To evaluate the risk of CVD and overall mortality after a first episode of VTE in women and to assess common risk factors for VTE and CVD. Patients/methods: We performed a cohort study inviting 1433 women with a previous VTE (exposed) and 1402 women without VTE (unexposed). The cohort was derived from TEHS, a Swedish population-based case-control study on risk factors for VTE in women age 18-64 years. The women were recruited in 2002-2009. During 2011 information on CVD and mortality was obtained from a questionnaire and from the Swedish Patient Register and the Cause of Death Register. Hazard ratios (HR) for CVD and their 95% confidence intervals (CI) were calculated using Cox regression. In multivariate analyses we adjusted for age, smoking, diabetes mellitus, hypertension and body mass index. Results: 2108 (75%) women (mean age 47 +/- 13 years) accepted participation. During the total follow up of 11,920 person years 35 (3.2%, 95% CI 0.7-2.1) among the exposed and 14 (1.4%, 95% CI 0.2-4.3) among the unexposed had any CVD event. The adjusted HR for CVD was 2.0 (95% CI 1.1-3.9) the adjusted HR for mortality was 2.3 (95% CI 1.2-4.6) Conclusion: Women with a previous VTE had a two-fold increased risk of CVD and overall mortality. Adjusting for cardiovascular risk factors only modestly changed the estimates.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 138, 80-85 p.
Keyword [en]
Cardiovascular disease, Cohort studies, Mortality, Venous thromboembolism, Women
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URN: urn:nbn:se:kth:diva-182779DOI: 10.1016/j.thromres.2015.11.039ISI: 000368811200014PubMedID: 26826509OAI: diva2:906046

QC 20160223

Available from: 2016-02-23 Created: 2016-02-23 Last updated: 2016-02-23Bibliographically approved

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Odeberg, Jacob
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Proteomics and NanobiotechnologyScience for Life Laboratory, SciLifeLab
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