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On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Applied Physical Chemistry. Università Degli Studi di Palermo, Italy.
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2016 (English)In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 6, no 4, 2582-2591 p.Article in journal (Refereed) PublishedText
Abstract [en]

Radiation-engineered poly(N-vinyl pyrrolidone) nanogels are very interesting biocompatible nanocarriers for i.v. administration of therapeutics and contrast agents for bioimaging. The manufacturing process is fast and effective, it grants excellent control of particle size and simultaneous sterilization of the formed nanogels. Interestingly, primary amino groups and carboxyl groups, useful for (bio) conjugation, are also formed in a dose-dependent fashion. In this paper, by means of both numerical simulations and experiments, the origin of nanogel size control and functionalization is investigated. This understanding offers a new dimension for the design and production of radiation-sculptured multifunctional nanocarriers from aqueous solutions of polymers.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2016. Vol. 6, no 4, 2582-2591 p.
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Chemical Sciences
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URN: urn:nbn:se:kth:diva-182875DOI: 10.1039/c5ra23926eISI: 000368193500008ScopusID: 2-s2.0-84954058310OAI: oai:DiVA.org:kth-182875DiVA: diva2:906444
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QC 20160224

Available from: 2016-02-24 Created: 2016-02-23 Last updated: 2016-02-24Bibliographically approved

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