On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions
2016 (English)In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 6, no 4, 2582-2591 p.Article in journal (Refereed) PublishedText
Radiation-engineered poly(N-vinyl pyrrolidone) nanogels are very interesting biocompatible nanocarriers for i.v. administration of therapeutics and contrast agents for bioimaging. The manufacturing process is fast and effective, it grants excellent control of particle size and simultaneous sterilization of the formed nanogels. Interestingly, primary amino groups and carboxyl groups, useful for (bio) conjugation, are also formed in a dose-dependent fashion. In this paper, by means of both numerical simulations and experiments, the origin of nanogel size control and functionalization is investigated. This understanding offers a new dimension for the design and production of radiation-sculptured multifunctional nanocarriers from aqueous solutions of polymers.
Place, publisher, year, edition, pages
Royal Society of Chemistry, 2016. Vol. 6, no 4, 2582-2591 p.
IdentifiersURN: urn:nbn:se:kth:diva-182875DOI: 10.1039/c5ra23926eISI: 000368193500008ScopusID: 2-s2.0-84954058310OAI: oai:DiVA.org:kth-182875DiVA: diva2:906444
QC 201602242016-02-242016-02-232016-02-24Bibliographically approved