Change search
ReferencesLink to record
Permanent link

Direct link
F11 is associated with recurrent VTE in women A prospective cohort study
Show others and affiliations
2016 (English)In: Thrombosis and Haemostasis, ISSN 0340-6245, Vol. 115, no 2, 406-414 p.Article in journal (Refereed) PublishedText
Abstract [en]

Genetic associations for the reoccurrence of venous thromboembolism (VTE) are not well described. Our aim was to investigate if common genetic variants, previously found to contribute to the prediction of first time thrombosis in women, were associated with risk of recurrence. The Thromboembolism Hormone Study (TEHS) is a Swedish nationwide case-control study (2002-2009). A cohort of 1,010 women with first time VTE was followed up until a recurrent event, death or November 2011. The genetic variants in F5 rs6025, F2 rs1799963, ABO rs514659, FGG rs2066865, F11 rs2289252, PROC rs1799810 and KNG1 rs710446 were assessed together with clinical variables. Recurrence rate was calculated as the number of events over the accumulated patient-time. Cumulative recurrence was calculated by Kaplan-Meier curve. Cox proportional-hazard model was used to estimate hazard ratios (HR) and 95 % confidence intervals (95 % CI) between groups. A total of 101 recurrent events occurred during a mean follow-up time of five years. The overall recurrence rate was 20 per 1,000 person-years (95 % CI; 16-24). The recurrence rate was highest in women with unprovoked first event and obesity. Carriers of the risk alleles of F5 rs6025 (HR=1.7 (95 % CI; 1.1-2.6)) and F11 rs2289252 (HR=1.8 (95 % CI; 1.1-3.0)) had significantly higher rates of recurrence compared to non-carriers. The cumulative recurrence was 2.5-fold larger in carriers of both F5 rs6025 and F11 rs2289252 than in non-carriers at five years follow-up. In conclusion, F5 rs6025 and F11 rs2289252 contributed to the risk of recurrent VTE and the combination is of potential clinical relevance for risk prediction.

Place, publisher, year, edition, pages
Schattauer Gmbh, 2016. Vol. 115, no 2, 406-414 p.
Keyword [en]
Epidemiology, polymorphism, single nucleotide, venous thrombosis, women, recurrence
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:kth:diva-183203DOI: 10.1160/TH15-06-0459ISI: 000369431700021PubMedID: 26423325ScopusID: 2-s2.0-84957559592OAI: oai:DiVA.org:kth-183203DiVA: diva2:908895
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceSwedish Heart Lung FoundationAFA InsuranceStockholm County Council, 560283; 20130508Swedish Research Council, 8691
Note

QC 20160303

Available from: 2016-03-03 Created: 2016-03-03 Last updated: 2016-03-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Odeberg, Jacob
By organisation
Proteomics and NanobiotechnologyScience for Life Laboratory, SciLifeLab
In the same journal
Thrombosis and Haemostasis
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 15 hits
ReferencesLink to record
Permanent link

Direct link