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Systems Proteomics View of the Endogenous Human Claudin Protein Family
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2016 (English)In: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 15, no 2, 339-359 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Claudius are the major transmembrane protein components of tight junctions in human endothelia and epithelia. Tissue-specific expression of claudin members suggests that this protein family is not only essential for sustaining the role of tight junctions in cell permeability control but also vital in organizing cell contact signaling by protein protein interactions. How this protein family is collectively processed and regulated is key to understanding the role of junctional proteins in preserving cell identity and tissue integrity. The focus of this review is to first provide a brief overview of the functional context, on the basis of the extensive body of claudin biology research that has been thoroughly reviewed, for endogenous human claudin members and then ascertain existing and future proteomics techniques that may be applicable to systematically characterizing the chemical forms and interacting protein partners of this protein family in human. The ability to elucidate claudin-based signaling networks may provide new insight into cell development and differentiation programs that are crucial to tissue stability and manipulation.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2016. Vol. 15, no 2, 339-359 p.
Keyword [en]
Membrane protein complexes, cell-contact signaling systems proteomics, membrane proteomics, targeted proteomics, top-down proteomics, chemical proteomics
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-183328DOI: 10.1021/acs.jproteome.5b00769ISI: 000369771700001PubMedID: 26680015ScopusID: 2-s2.0-84957646743OAI: diva2:910487

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Available from: 2016-03-09 Created: 2016-03-07 Last updated: 2016-03-19Bibliographically approved

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Lundberg, Emma Käller
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School of Biotechnology (BIO)Science for Life Laboratory, SciLifeLab
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