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Trehalose-Conjugated, Photofunctionalized Mesoporous Silica Nanoparticles for Efficient Delivery of Isoniazid into Mycobacteria
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
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2015 (English)In: ACS BIOMATERIALS-SCIENCE & ENGINEERING, ISSN 2373-9878, Vol. 1, no 12, p. 1250-1255Article in journal (Refereed) Published
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Abstract [en]

Glyconanoparticle carriers have been synthesized and efficiently delivered into mycobacteria. Mesoporous silica nanoparticles were functionalized with a,a-trehalose through azide-mediated surface photoligation, and loaded with the antitubercular drug isoniazid. The glyconanoparticles showed high isoniazid loading capacity and higher antimicrobial activity than the free drug.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2015. Vol. 1, no 12, p. 1250-1255
Keywords [en]
mesoporous silica nanoparticle, drug delivery, isoniazid, trehalose
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-183701DOI: 10.1021/acsbiomaterials.5b00274ISI: 000370675300008Scopus ID: 2-s2.0-84969257049OAI: oai:DiVA.org:kth-183701DiVA, id: diva2:913122
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QC 20160319

Available from: 2016-03-19 Created: 2016-03-18 Last updated: 2016-03-19Bibliographically approved

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