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UVA radiation induced ultrafast electron transfer from a food carcinogen benzo[a]pyrene to organic molecules, biological macromolecules, and inorganic nano structures
Water Research Center, Sultan Qaboos University, P.O. Box 17, 123 Al-Khoudh, Oman.ORCID iD: 0000-0002-0074-3504
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2013 (English)In: Journal of Physical Chemistry B, ISSN 1520-6106, E-ISSN 1520-5207, Vol. 117, no 14, 3726-3737 p.Article in journal (Refereed) Published
Abstract [en]

Reactions involving electron transfer (ET) and reactive oxygen species (ROS) play a pivotal role in carcinogenesis and cancer biochemistry. Our present study emphasizes UVA radiation induced ET reaction as one of the key aspects of a potential carcinogen, benzo[a]pyrene (BP), in the presence of a wide variety of molecules covering organic p-benzoquinone (BQ), biological macromolecules like calf-thymus DNA (CT-DNA), human serum albumin (HSA) protein, and inorganic zinc oxide (ZnO) nanorods (NRs). Steady-state and picosecond-resolved fluorescence spectroscopy have been used to monitor such ET reactions. Physical consequences of BP association with CT-DNA have been investigated through temperature-dependent circular dichroism (CD) spectroscopy. The temperature-dependent steady-state, picosecond-resolved fluorescence lifetime and anisotropy studies reveal the effect of temperature on the perturbation of such ET reactions from BP to biological macromolecules, highlighting their temperature-dependent association. Furthermore, the electron-donating property of BP has been corroborated by measuring wavelength-dependent photocurrent in a BP-anchored ZnO NR-based photodevice, offering new physical insights for the carcinogenic study of BP.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2013. Vol. 117, no 14, 3726-3737 p.
National Category
Nano Technology
Identifiers
URN: urn:nbn:se:kth:diva-175198DOI: 10.1021/jp312536xISI: 000317552700004ScopusID: 2-s2.0-84876255191OAI: oai:DiVA.org:kth-175198DiVA: diva2:914339
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QC 20160330

Available from: 2016-03-23 Created: 2015-10-10 Last updated: 2016-03-30Bibliographically approved

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Dutta, Joydeep
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