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Estrogen receptor beta as target for colorectal cancer prevention
KTH, School of Biotechnology (BIO). KTH, Centres, Science for Life Laboratory, SciLifeLab. University of Houston, USA; Karolinska Institutet, Sweden.ORCID iD: 0000-0002-0602-2062
2016 (English)In: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 372, no 1, 48-56 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow development and the capacity for early diagnosis, current preventive approaches are not sufficient. However, a role for estrogen has been demonstrated in multiple epidemiologic studies, which may benefit CRC prevention. A large body of evidence from preclinical studies indicates that expression of the estrogen receptor beta (ER beta/ESR2) demonstrates an inverse relationship with the presence of colorectal polyps and stage of tumors, and can mediate a protective response. Natural compounds, including phytoestrogens, or synthetic ER beta selective agonists, can activate or upregulate ER beta in the colon and promote apoptosis in preclinical models and in clinical experience. Importantly, this activity has been associated with a reduction in polyp formation and, in rodent models of CRC, has been shown to lower incidence of colon adenocarcinoma. Collectively, these findings indicate that targeted activation of ER beta may represent a novel clinical approach for management of colorectal adenomatous polyps and prevention of colorectal carcinoma in patients at risk for this condition. In this review, we discuss the potential of new chemopreventive or dietary approaches based on estrogen signaling.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 372, no 1, 48-56 p.
Keyword [en]
Colorectal cancer, Estrogen, Estrogen receptor beta, Phytoestrogens, Prevention, Gene expression
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:kth:diva-184022DOI: 10.1016/j.canlet.2015.12.009ISI: 000370832600005PubMedID: 26708506ScopusID: 2-s2.0-84958213395OAI: oai:DiVA.org:kth-184022DiVA: diva2:914502
Note

QC 20160324

Available from: 2016-03-24 Created: 2016-03-22 Last updated: 2016-03-24Bibliographically approved

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Williams, Cecilia
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