Comprehensive RNA sequencing of healthy human endometrium at two time points of the menstrual cycle
(English)Manuscript (preprint) (Other academic)
Endometrium receptivity is crucial for implantation and establishment of a normal pregnancy. The process of receptivity and subsequent implantation is still far from understood. This paper present a comprehensive transcriptome of the human endometrium comparing endometrial biopsies from proliferative phase with consecutive biopsies during window of implantation. The result shows a clear difference in expression between the two time points using both total and small RNA sequencing. 3297 mRNAs, 516 long non-coding RNAs and 102 small non-coding RNAs were identified as statistically differentially expressed between the two time points. We show a thorough description of the change in mRNA between the two time points and lists lncRNAs, snoRNAs and snRNAs not previously reported in the healthy human endometrium. In conclusion this paper reports in detail the shift in RNA expression from the unresponsive to receptive endometrium.
RNA-seq, endometrium, menstruation cycle, differential expression, small RNA, total RNA
Endocrinology and Diabetes
IdentifiersURN: urn:nbn:se:kth:diva-184156OAI: oai:DiVA.org:kth-184156DiVA: diva2:915144
FunderSwedish Research Council
QC 201604042016-03-292016-03-292016-04-04Bibliographically approved