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Studying solutions at high shear rates: a dedicated microfluidics setup
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2016 (English)In: Journal of Synchrotron Radiation, ISSN 0909-0495, E-ISSN 1600-5775, Vol. 23, 480-486 p.Article in journal (Refereed) PublishedText
Abstract [en]

The development of a dedicated small-angle X-ray scattering setup for the investigation of complex fluids at different controlled shear conditions is reported. The setup utilizes a microfluidics chip with a narrowing channel. As a consequence, a shear gradient is generated within the channel and the effect of shear rate on structure and interactions is mapped spatially. In a first experiment small-angle X-ray scattering is utilized to investigate highly concentrated protein solutions up to a shear rate of 300000 s(-1). These data demonstrate that equilibrium clusters of lysozyme are destabilized at high shear rates.

Place, publisher, year, edition, pages
INT UNION CRYSTALLOGRAPHY , 2016. Vol. 23, 480-486 p.
Keyword [en]
shear, complex solutions, small-angle X-ray scattering (SAXS), microfluidics, lysozyme, aggregation, rheology, protein interaction, beamline setup
National Category
Materials Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-184963DOI: 10.1107/S1600577515024856ISI: 000371387900014PubMedID: 26917136ScopusID: 2-s2.0-84959274343OAI: oai:DiVA.org:kth-184963DiVA: diva2:917810
Note

QC 20160407

Available from: 2016-04-07 Created: 2016-04-07 Last updated: 2016-04-07Bibliographically approved

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Dedinaite, AndraClaesson, Per M.
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