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Squalene hopene cyclases: highly promiscuous and evolvable catalysts for stereoselective CC and CX bond formation
Universitaet Stuttgart, Germany.ORCID iD: 0000-0002-4066-2776
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2013 (English)In: Current opinion in chemical biology, ISSN 1367-5931, E-ISSN 1879-0402, Vol. 17, no 2, 293-300 p.Article in journal (Refereed) Published
Abstract [en]

A review. We review here how the inherent promiscuous nature, as well as the evolvability of terpene cyclase enzymes enables new applications in chem. We mainly focus on squalene hopene cyclases, class II triterpene synthases that use a proton-initiated cationic polycyclization cascade to form carbopolycyclic products. We highlight recent findings to demonstrate that these enzymes are capable of activating different functionalities other than the traditional terminal isoprene CC-group as well as being compatible with a wide range of nucleophiles beyond the 'ene-functionality'. Thus, squalene hopene cyclases demonstrate a great potential to be used as a toolbox for general Bronsted acid catalysis.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 17, no 2, 293-300 p.
Keyword [en]
review squalene hopene cyclase promiscuous evolvable catalyst stereoselectivity
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-185568DOI: 10.1016/j.cbpa.2013.01.016ISI: 000318749500022ScopusID: 2-s2.0-84876731984OAI: diva2:922318

QC 20160429

Available from: 2016-04-22 Created: 2016-04-22 Last updated: 2016-04-29Bibliographically approved

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Syren, Per-Olof
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