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Engineering Cellular Metabolism
KTH, School of Biotechnology (BIO), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab. Department of Biology and Biological Engineering, Chalmers University of Technology, Sweden.
2016 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 164, no 6, 1185-1197 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Metabolic engineering is the science of rewiring the metabolism of cells to enhance production of native metabolites or to endow cells with the ability to produce new products. The potential applications of such efforts are wide ranging, including the generation of fuels, chemicals, foods, feeds, and pharmaceuticals. However, making cells into efficient factories is challenging because cells have evolved robust metabolic networks with hard-wired, tightly regulated lines of communication between molecular pathways that resist efforts to divert resources. Here, we will review the current status and challenges of metabolic engineering and will discuss how new technologies can enable metabolic engineering to be scaled up to the industrial level, either by cutting off the lines of control for endogenous metabolism or by infiltrating the system with disruptive, heterologous pathways that overcome cellular regulation.

Place, publisher, year, edition, pages
Cell Press , 2016. Vol. 164, no 6, 1185-1197 p.
National Category
Cell Biology
URN: urn:nbn:se:kth:diva-185641DOI: 10.1016/j.cell.2016.02.004ISI: 000372784900016PubMedID: 26967285ScopusID: 2-s2.0-84960460639OAI: diva2:923616
Novo NordiskKnut and Alice Wallenberg FoundationSwedish Research Council

QC 20160427

Available from: 2016-04-27 Created: 2016-04-25 Last updated: 2016-04-27Bibliographically approved

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