Change search
ReferencesLink to record
Permanent link

Direct link
Exercise during Short-Term and Long-Term Continuous Exposure to Hypoxia Exacerbates Sleep-Related Periodic Breathing
Show others and affiliations
2016 (English)In: Sleep, ISSN 0161-8105, E-ISSN 1550-9109, Vol. 39, no 4, 773-783 p.Article in journal (Refereed) PublishedText
Abstract [en]

Study Objectives: Exposure to hypoxia elevates chemosensitivity, which can lead to periodic breathing. Exercise impacts gas exchange, altering chemosensitivity; however, interactions between sleep, exercise and chronic hypoxic exposure have not been examined. This study investigated whether exercise exacerbates sleep-related periodic breathing in hypoxia. Methods: Two experimental phases. Short-Term Phase: a laboratory controlled, group-design study in which 16 active, healthy men (age: 25 +/- 3 y, height: 1.79 +/- 0.06 m, mass: 74 +/- 8 kg) were confined to a normobaric hypoxic environment (FIO2 = 0.139 +/- 0.003, 4,000 m) for 10 days, after random assignment to a sedentary (control, CON) or cycle-exercise group (EX). Long-Term Phase: conducted at the Concordia Antarctic Research Station (3,800 m equivalent at the Equator) where 14 men (age: 36 +/- 9 y, height: 1.77 +/- 0.09 m, mass: 75 +/- 10 kg) lived for 12-14 months, continuously confined. Participants were stratified post hoc based on self-reported physical activity levels. We quantified apnea-hypopnea index (AHI) and physical activity variables. Results: Short-Term Phase: mean AHI scores were significantly elevated in the EX group compared to CON (Night1 = CON: 39 +/- 51, EX: 91 +/- 59; Night10 = CON: 32 +/- 32, EX: 92 +/- 48; P = 0.046). Long-Term Phase: AHI was correlated to mean exercise time (R-2 = 0.4857; P = 0.008) and the coefficient of variation in night oxyhemoglobin saturation (SpO(2); R-2 = 0.3062; P = 0.049). Conclusions: Data indicate that exercise (physical activity) per se affects night SpO(2) concentrations and AHI after a minimum of two bouts of moderateintensity hypoxic exercise, while habitual physical activity in hypobaric hypoxic confinement affects breathing during sleep, up to 13+ months' duration

Place, publisher, year, edition, pages
Associated Professional Sleep Societies , 2016. Vol. 39, no 4, 773-783 p.
Keyword [en]
Antarctica, sleep apnea, confinement, cycling, high altitude, oxygen saturation
National Category
URN: urn:nbn:se:kth:diva-185621DOI: 10.5665/sleep.5626ISI: 000373186900009ScopusID: 2-s2.0-84962467344OAI: diva2:924786

QC 20160429

Available from: 2016-04-29 Created: 2016-04-25 Last updated: 2016-04-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Eiken, Ola
By organisation
Environmental Physiology
In the same journal

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 5 hits
ReferencesLink to record
Permanent link

Direct link