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3D Bioprinting of Tissue/Organ Models
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
2016 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 55, no 15, 4650-4665 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Invitro tissue/organ models are useful platforms that can facilitate systematic, repetitive, and quantitative investigations of drugs/chemicals. The primary objective when developing tissue/organ models is to reproduce physiologically relevant functions that typically require complex culture systems. Bioprinting offers exciting prospects for constructing 3D tissue/organ models, as it enables the reproducible, automated production of complex living tissues. Bioprinted tissues/organs may prove useful for screening novel compounds or predicting toxicity, as the spatial and chemical complexity inherent to native tissues/organs can be recreated. In this Review, we highlight the importance of developing 3D invitro tissue/organ models by 3D bioprinting techniques, characterization of these models for evaluating their resemblance to native tissue, and their application in the prioritization of lead candidates, toxicity testing, and as disease/tumor models.

Place, publisher, year, edition, pages
John Wiley & Sons, 2016. Vol. 55, no 15, 4650-4665 p.
Keyword [en]
3D bioprinting, biomimetics, drug discovery, tissue/organ models, toxicology
National Category
Nano Technology
Identifiers
URN: urn:nbn:se:kth:diva-185981DOI: 10.1002/anie.201505062ISI: 000373615900004PubMedID: 26895542ScopusID: 2-s2.0-84962208551OAI: oai:DiVA.org:kth-185981DiVA: diva2:926908
Note

QC 20160510

Available from: 2016-05-10 Created: 2016-04-29 Last updated: 2016-05-17Bibliographically approved

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Pati, FalguniGantelius, JesperSvahn, Helene Andersson
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