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Signal amplification using magnetic bead chains in microfluidic electrochemical biosensors
KTH, School of Biotechnology (BIO), Protein Technology. Department of Microsystems Engineering - IMTEK, University of Freiburg, Freiburg, Germany.
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2015 (English)In: 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, IEEE , 2015, 1601-1604 p.Conference paper (Refereed)Text
Abstract [en]

We present a novel approach to increase the sensitivity of microfluidic biosensor platforms using magnetic micro-bead chains. An almost 2-fold sensitivity enhancement is achieved by introducing a magnetic field gradient along a microfluidic channel by means of a soft-magnetic lattice with lattice spacings down to 100 μm. The magnetic field gradient induces self-assembly of the magnetic beads in chains or clusters and thus improves the active contact between analyte and beads. This facile strategy significantly increases the active bead surface while allowing for complete independence of traditional biosensor materials and channel geometries, chip-reusability and shortened measurement times. Bead chain properties were validated with optical microscopy in a glass capillary and with electrochemical measurements via glucose oxidase (GOx) labels on an integrated microfluidic chip fabricated in dry-film photo resist technology (DFR).

Place, publisher, year, edition, pages
IEEE , 2015. 1601-1604 p.
Keyword [en]
bead chains, biosensor, dry-film resist, glucose oxidase, lab-on-a-chip, Magnetic beads, microfluidics
National Category
Condensed Matter Physics
URN: urn:nbn:se:kth:diva-187139DOI: 10.1109/TRANSDUCERS.2015.7181246ISI: 000380461400399ScopusID: 2-s2.0-84955503936ISBN: 978-1-4799-8955-3OAI: diva2:929061
Conference of 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015

QC 20160517

Available from: 2016-05-17 Created: 2016-05-17 Last updated: 2016-09-02Bibliographically approved

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Horak, Josef
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Protein Technology
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