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A nanotube/polymer composite biosensing thin-film transistor platform for C-reactive protein detection
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2015 (English)In: IEEE-NANO 2015 - 15th International Conference on Nanotechnology, IEEE conference proceedings, 2015, 1282-1284 p.Conference paper (Refereed)Text
Abstract [en]

In the present study, a back-gate thin-film transistor (TFT) based on a single-walled carbon nanotubes (SWCNTs)/poly(9,9-dioctylfluorene-co-bithiophene) (F8T2) composite semiconductor is proposed as electronic label-free immunosensor for the detection of the C-reactive protein (CRP). The nano-composite semiconducting ultra-thin film is deposited on the channel area of the TFT and is functionalized with a monoclonal anti-CRP antibody coating acting as biorecognition layer. The immunesensor was then used for the selective detection of the CRP both in phosphate buffered saline (PBS) solution and in human serum samples. The proposed immunosensor exhibits high current (10 - 20 μA) and good field-effect carriers mobility. Furthermore, the CRP could be revealed at a detection limit as low as 1 mg/L and in a wide dynamic range (from 0.4 nM to 2.2 μM).

Place, publisher, year, edition, pages
IEEE conference proceedings, 2015. 1282-1284 p.
Keyword [en]
C-reactive protein detection, label free immunosensor, polymer nano-composite, thin-film transistors, Carbon, Chemical detection, Immunosensors, Nanocomposites, Nanotechnology, Nanotubes, Proteins, Semiconducting organic compounds, Single-walled carbon nanotubes (SWCN), Thin film transistors, Thin films, Transistors, Ultrathin films, Yarn, C-reactive proteins, Electronic labels, Label-free immunosensor, Phosphate buffered saline solutions, Polymer nanocomposite, Selective detection, Single-walled carbon nanotube (SWCNTs), Wide dynamic range, Nanocomposite films
National Category
Analytical Chemistry
URN: urn:nbn:se:kth:diva-188332DOI: 10.1109/NANO.2015.7388866ScopusID: 2-s2.0-84964319082ISBN: 9781467381550OAI: diva2:936207
15th IEEE International Conference on Nanotechnology, IEEE-NANO 2015, 27 July 2015 through 30 July 2015

QC 20160613

Available from: 2016-06-13 Created: 2016-06-09 Last updated: 2016-06-13Bibliographically approved

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Zheng, Lirong
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Industrial and Medical Electronics
Analytical Chemistry

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