Change search
ReferencesLink to record
Permanent link

Direct link
Pressure distension in leg vessels as influenced by prolonged bed rest and a pressure habituation regimen
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
2016 (English)In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 120, no 12, 1458-1465 p.Article in journal (Refereed) Published
Abstract [en]

Bed rest increases pressure distension in arteries, arterioles, and veins of the leg. We hypothesized that bed-rest-induced deconditioning of leg vessels is governed by the removal of the local increments in transmural pressure induced by assuming erect posture and, therefore, can be counteracted by intermittently increasing local transmural pressure during the bed rest. Ten men underwent 5 wk of horizontal bed rest. A subatmospheric pressure (-90 mmHg) was intermittently applied to one lower leg [pressure habituation (PH) leg]. Vascular pressure distension was investigated before and after the bed rest, both in the PH and control (CN) leg by increasing local distending pressure, stepwise up to +200 mmHg. Vessel diameter and blood flow were measured in the posterior tibial artery and vessel diameter in the posterior tibial vein. In the CN leg, bed rest led to 5-fold and 2.7-fold increments (P < 0.01) in tibial artery pressure-distension and flow responses, respectively, and to a 2-fold increase in tibial vein pressure distension. In the PH leg, arterial pressure-distension and flow responses were unaffected by bed rest, whereas bed rest led to a 1.5-fold increase in venous pressure distension. It thus appears that bed-rest-induced deconditioning of leg arteries, arterioles, and veins is caused by removal of gravity-dependent local pressure loads and may be abolished or alleviated by a local pressure-habituation regimen.

Place, publisher, year, edition, pages
American Physiological Society , 2016. Vol. 120, no 12, 1458-1465 p.
Keyword [en]
arterial stiffness, hypotension, vascular remodeling, venous compliance
National Category
Physiology
Identifiers
URN: urn:nbn:se:kth:diva-188658DOI: 10.1152/japplphysiol.00922.2015PubMedID: 27079693OAI: oai:DiVA.org:kth-188658DiVA: diva2:937875
Funder
Swedish National Space Board, 151/12
Note

QC 20160715

Available from: 2016-06-16 Created: 2016-06-16 Last updated: 2016-07-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Eiken, OlaKölegård, Roger
By organisation
Environmental Physiology
In the same journal
Journal of applied physiology
Physiology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 22 hits
ReferencesLink to record
Permanent link

Direct link