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Antigen arrays for profiling autoantibody repertoires
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
2016 (English)In: Bioanalysis, ISSN 1757-6180, E-ISSN 1757-6199, Vol. 8, no 10, 1105-1126 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Autoantibodies are a key component for the diagnosis, prognosis and monitoring of various diseases. In order to discover novel autoantibody targets, highly multiplexed assays based on antigen arrays hold a great potential and provide possibilities to analyze hundreds of body fluid samples for their reactivity pattern against thousands of antigens in parallel. Here, we provide an overview of the available technologies for producing antigen arrays, highlight some of the technical and methodological considerations and discuss their applications as discovery tools. Together with recent studies utilizing antigen arrays, we give an overview on how the different types of antigen arrays have and will continue to deliver novel insights into autoimmune diseases among several others.

Place, publisher, year, edition, pages
FUTURE SCI LTD , 2016. Vol. 8, no 10, 1105-1126 p.
Keyword [en]
affinity proteomics, antigen microarrays, autoantibodies, autoantibody profiling, autoimmunity, protein biomarker discovery
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-188739DOI: 10.4155/bio.16.31ISI: 000376676800009PubMedID: 27097564ScopusID: 2-s2.0-84966692085OAI: oai:DiVA.org:kth-188739DiVA: diva2:938856
Note

QC 20160617

Available from: 2016-06-17 Created: 2016-06-17 Last updated: 2016-06-17Bibliographically approved

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