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Minor enantiomer recycling - a strategy to improve enantioselectivity
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
2016 (English)In: Pure and Applied Chemistry, ISSN 0033-4545, E-ISSN 1365-3075, Vol. 88, no 4, 309-316 p.Article in journal (Refereed) PublishedText
Abstract [en]

In enantioselective reactions, the major, desired enantiomer is commonly obtained along with the minor, undesired enantiomer. By continuous recycling of this undesired enantiomer back to starting material, products with improved enantiomeric purity can be obtained. Such in situ minor enantiomer recycling can be accomplished by coupling the catalytic reaction to an exergonic transformation of a sacrificial reagent. The method has been applied to the synthesis of O-acylated cyanohydrins, which serve as starting materials for a variety of biologically active compounds.

Place, publisher, year, edition, pages
2016. Vol. 88, no 4, 309-316 p.
Keyword [en]
bioactive molecules, biocatalysis, chirality, enantioselectivity, ESOC-19, Lewis acids, organic synthesis
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-189100DOI: 10.1515/pac-2015-1205ISI: 000377216400002ScopusID: 2-s2.0-84974725370OAI: oai:DiVA.org:kth-189100DiVA: diva2:944530
Note

QC 20160629

Available from: 2016-06-29 Created: 2016-06-27 Last updated: 2016-06-29Bibliographically approved

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Moberg, Christina
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