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Graphene Meets Microbubbles: A Superior Contrast Agent for Photoacoustic Imaging
KTH, School of Technology and Health (STH), Medical Engineering. Karolinska Institutet (KI), CLINTEC – Division of Medical Imaging and Technology. (Contrast Enhanced Medical Imaging)ORCID iD: 0000-0002-3699-396X
Number of Authors: 9
2016 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 8, no 25, 16465-16475 p.Article in journal (Refereed) Published
Abstract [en]

Coupling graphene with a soft polymer surface offers the possibility to build hybrid constructs with new electrical, optical, and mechanical properties. However, the low reactivity of graphene is a hurdle in the synthesis of such systems which is often bypassed by oxidizing its carbon planar structure. However, the defects introduced with this process jeopardize the properties of graphene. In this paper we present a different approach, applicable to many different polymer surfaces, which uses surfactant assisted ultrasonication to exfoliate, and simultaneously suspend, graphene in water in its intact form. Tethering pristine graphene sheets to the surfaces is accomplished by using suitable reactive functional groups of the surfactant scaffold. We focused on applying this approach to the fabrication of a hybrid system, made of pristine graphene tethered to poly(vinyl alcohol) based microbubbles (PVA MBs), designed for enhancing photoacoustic signals. Photoacoustic imaging (PAI) is a powerful preclinical diagnostic tool which provides real time images at a resolution of 40 μm. The leap toward clinical imaging has so far been hindered by the limited tissues penetration of near-infrared (NIR) pulsed laser radiation. Many academic and industrial research laboratories have met this challenge by designing devices, each with pros and cons, to enhance the photoacoustic (PA) signal. The major advantages of the hybrid graphene/PVA MBs construct, however, are (i) the preservation of graphene properties, (ii) biocompatibility, a consequence of the robust anchoring of pristine graphene to the bioinert surface of the PVA bubble, and (iii) a very good enhancement in a NIR spectral region of the PA signal, which does not overlap with the signals of PA active endogenous molecules such as hemoglobin.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2016. Vol. 8, no 25, 16465-16475 p.
Keyword [en]
graphene, microbubbles, photoacoustics, surfactant, ultrasound
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-189876DOI: 10.1021/acsami.6b04184ISI: 000378984800069Scopus ID: 2-s2.0-84976897470OAI: oai:DiVA.org:kth-189876DiVA: diva2:949641
Note

QC 20160727

Available from: 2016-07-21 Created: 2016-07-21 Last updated: 2017-01-10Bibliographically approved

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