Kinetic Self-Sorting of Dynamic Covalent Catalysts with Systemic Feedback Regulation
2016 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 138, no 25, 7836-7839 p.Article in journal (Refereed) PublishedText
Constructing small molecule systems that mimic the functionality exhibited in biological reaction networks is a key objective of systems chemistry. Herein, we report the development of a dynamic catalytic system where the catalyst activity is modulated through a dynamic covalent bond. By connecting a thermodynamically controlled rearrangement process to resolution under kinetic control, the catalyst system underwent kinetic self sorting, resulting in amplification of a more reactive catalyst while establishing a catalytic feedback mechanism. The dynamic catalyst system furthermore responded to catalytic events by self-perturbation to regulate its own activity, which in the case of upregulation gave rise to systemic autocatalytic behavior.
Place, publisher, year, edition, pages
American Chemical Society , 2016. Vol. 138, no 25, 7836-7839 p.
IdentifiersURN: urn:nbn:se:kth:diva-190675DOI: 10.1021/jacs.6b04250ISI: 000378984300009PubMedID: 27304874ScopusID: 2-s2.0-84976597278OAI: oai:DiVA.org:kth-190675DiVA: diva2:953017
QC 201608162016-08-162016-08-122016-08-16Bibliographically approved