Controllable degradation of medical magnesium by electrodeposited composite films of mussel adhesive protein (Mefp-1) and chitosan
2016 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 478, 246-255 p.Article in journal (Refereed) Published
To control the degradation rate of medical magnesium in body fluid environment, biocompatible films composed of Mussel Adhesive Protein (Mefp-1) and chitosan were electrodeposited on magnesium surface in cathodic constant current mode. The compositions and structures of the films were characterized by atomic force microscope (AFM), scanning electron microscope (SEM) and infrared reflection absorption spectroscopy (IRAS). And the corrosion protection performance was investigated using electrochemical measurements and immersion tests in simulated body fluid (Hanks' solution). The results revealed that Mefp-1 and chitosan successfully adhered on the magnesium surface and formed a protective film. Compared with either single Mefp-1 or single chitosan film, the composite film of chitosan/Mefp-1/chitosan (CPC (chitosan/Mefp-1/chitosan)) exhibited lower corrosion current density, higher polarization resistance and more homogenous corrosion morphology and thus was able to effectively control the degradation rate of magnesium in simulated body environment. In addition, the active attachment and spreading of MC3T3-E1 cells on the CPC film coated magnesium indicated that the CPC film was significantly able to improve the biocompatibility of the medical magnesium.
Place, publisher, year, edition, pages
Academic Press, 2016. Vol. 478, 246-255 p.
Mussel adhesive protein (Mefp-1), Chitosan, Magnesium, Corrosion protection, Biocompatiblity
IdentifiersURN: urn:nbn:se:kth:diva-192382DOI: 10.1016/j.jcis.2016.06.001ISI: 000380385500028PubMedID: 27309944ScopusID: 2-s2.0-84973487306OAI: oai:DiVA.org:kth-192382DiVA: diva2:968997
QC 201609132016-09-132016-09-122016-09-13Bibliographically approved