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Shear Wave Elastography Quantifies Stiffness in Ex Vivo Porcine Artery with Stiffened Arterial Region
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging. Karolinska Institutet, Sweden.ORCID iD: 0000-0002-2487-7400
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging. Karolinska Institutet, Sweden.ORCID iD: 0000-0002-9654-447X
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2016 (English)In: Ultrasound in Medicine and Biology, ISSN 0301-5629, E-ISSN 1879-291X, Vol. 42, no 10, 2423-2435 p.Article in journal (Refereed) Published
Abstract [en]

Five small porcine aortas were used as a human carotid artery model, and their stiffness was estimatedusing shear wave elastography (SWE) in the arterial wall and a stiffened artery region mimicking a stiff plaque. Tooptimize the SWE settings, shear wave bandwidth was measured with respect to acoustic radiation force pushlength and number of compounded angles used for motion detection with plane wave imaging. The mean arterialwall and simulated plaque shear moduli varied from 41 ± 5 to 97 ± 10 kPa and from 86 ± 13 to 174 ± 35 kPa, respectively,over the pressure range 20–120 mmHg. The results revealed that a minimum bandwidth of approximately1500 Hz is necessary for consistent shear modulus estimates, and a high pulse repetition frequency using no imagecompounding is more important than a lower pulse repetition frequency with better image quality when estimatingarterial wall and plaque stiffness using SWE.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 42, no 10, 2423-2435 p.
Keyword [en]
Artery, Arteriosclerosis, Atherosclerosis, Elasticity, Ex vivo, Plaque, Phase velocity, Shear wave elastography, Ultrasound
National Category
Medical Image Processing
Research subject
Medical Technology
Identifiers
URN: urn:nbn:se:kth:diva-192857DOI: 10.1016/j.ultrasmedbio.2016.05.021ISI: 000388314600008PubMedID: 27425151Scopus ID: 2-s2.0-84999074904OAI: oai:DiVA.org:kth-192857DiVA: diva2:972538
Note

QC 20160921

Available from: 2016-09-21 Created: 2016-09-21 Last updated: 2017-11-21Bibliographically approved
In thesis
1. Ultrasonic Methods for Quantitative Carotid Plaque Characterization
Open this publication in new window or tab >>Ultrasonic Methods for Quantitative Carotid Plaque Characterization
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Cardiovascular diseases are the leading causes of death worldwide and improved diagnostic methods are needed for early intervention and to select the most suitable treatment for patients. Currently, carotid artery plaque vulnerability is typically determined by visually assessing ultrasound B-mode images, which is influenced by user-subjectivity. Since plaque vulnerability is correlated to the mechanical properties of the plaque, quantitative techniques are needed to estimate plaque stiffness as a surrogate for plaque vulnerability, which would reduce subjectivity during plaque assessment. The work in this thesis focused on three noninvasive ultrasound-based techniques to quantitatively assess plaque vulnerability and measure arterial stiffness. In Study I, a speckle tracking algorithm was validated in vitro to assess strain in common carotid artery (CCA) phantom plaques and thereafter applied in vivo to carotid atherosclerotic plaques where the strain results were compared to visual assessments by experienced physicians. In Study II, hard and soft CCA phantom plaques were characterized with shear wave elastography (SWE) by using phase and group velocity analysis while being hydrostatically pressurized followed by validating the results with mechanical tensile testing. In Study III, feasibility of assessing the stiffness of simulated plaques and the arterial wall with SWE was demonstrated in an ex vivo setup in small porcine aortas used as a human CCA model. In Study IV, SWE and pulse wave imaging (PWI) were compared when characterizing homogeneous CCA soft phantom plaques. The techniques developed in this thesis have demonstrated potential to characterize carotid artery plaques. The results show that the techniques have the ability to noninvasively evaluate the mechanical properties of carotid artery plaques, provide additional data when visually assessing B-mode images, and potentially provide improved diagnoses for patients suffering from cerebrovascular diseases.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2016. 70 p.
Series
TRITA-STH : report, ISSN 1653-3836 ; 2016:08
Keyword
Atherosclerosis, Cardiovascular Disease, Carotid Artery, Elasticity, ex vivo, in vivo, Phantom, Plaque, Polyvinyl Alcohol, Pulse Wave Imaging, Shear Wave Elastography, Speckle Tracking, Stroke, Ultrasound
National Category
Medical Image Processing
Research subject
Medical Technology
Identifiers
urn:nbn:se:kth:diva-192339 (URN)978-91-7729-085-8 (ISBN)
Public defence
2016-10-13, T2, Hälsovägen 11c, Huddinge, 15:05 (English)
Opponent
Supervisors
Note

Doctoral thesis in medical technology and medical sciences

QC 20160921

Available from: 2016-09-21 Created: 2016-09-09 Last updated: 2016-09-21Bibliographically approved

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