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Recent trends in metabolic engineering of microorganisms for the production of advanced biofuels
KTH, School of Biotechnology (BIO), Bioprocess Technology (closed 20130101). (Gen Larsson)ORCID iD: 0000-0002-3314-6060
2016 (English)In: Current opinion in chemical biology, ISSN 1367-5931, E-ISSN 1879-0402, Vol. 35, 10-21 p.Article in journal (Refereed) Published
Abstract [en]

As climate change has become one of the major global risks, our heavy dependence on petroleum-derived fuels has received much public attention. To solve such problems, production of sustainable fuels has been intensively studied over the past years. Thanks to recent advances in synthetic biology and metabolic engineering technologies, bio-based platforms for advanced biofuels production have been developed using various microorganisms. The strategies for production of advanced biofuels have converged upon four major metabolic routes: the 2-ketoacid pathway, the fatty acid synthesis (FAS) pathway, the isoprenoid pathway, and the reverse β-oxidation pathway. Additionally, the polyketide synthesis pathway has recently been attracting interest as a promising alternative biofuel production route. In this article, recent trends in advanced biofuels production are reviewed by categorizing them into three types of advanced biofuels: alcohols, biodiesel and jet fuel, and gasoline. Focus is given on the strategies of employing synthetic biology and metabolic engineering for the development of microbial strains producing advanced fuels. Finally, the prospects for future advances needed to achieve much more efficient bio-based production of advanced biofuels are discussed, focusing on designing advanced biofuel production pathways coupled with screening, modifying, and creating novel enzymes.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 35, 10-21 p.
National Category
Industrial Biotechnology
URN: urn:nbn:se:kth:diva-193008DOI: 10.1016/j.cbpa.2016.08.003ScopusID: 2-s2.0-84982306147OAI: diva2:974212

QC 20160926

Available from: 2016-09-26 Created: 2016-09-26 Last updated: 2016-09-26Bibliographically approved

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