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Prospects of microbial cell factories developed through systems metabolic engineering
KTH, School of Biotechnology (BIO), Industrial Biotechnology. (Gen Larsson)ORCID iD: 0000-0002-3314-6060
2016 (English)In: Microbial Biotechnology, ISSN 1751-7907, E-ISSN 1751-7915, Vol. 9, no 5, 610-617 p.Article in journal (Refereed) Published
Abstract [en]

While academic-level studies on metabolic engineering of microorganisms for production of chemicals and fuels are ever growing, a significantly lower number of such production processes have reached commercial-scale. In this work, we review the challenges associated with moving from laboratory-scale demonstration of microbial chemical or fuel production to actual commercialization, focusing on key requirements on the production organism that need to be considered during the metabolic engineering process. Metabolic engineering strategies should take into account techno-economic factors such as the choice of feedstock, the product yield, productivity and titre, and the cost effectiveness of midstream and downstream processes. Also, it is important to develop an industrial strain through metabolic engineering for pathway construction and flux optimization together with increasing tolerance to products and inhibitors present in the feedstock, and ensuring genetic stability and strain robustness under actual fermentation conditions

Place, publisher, year, edition, pages
John Wiley & Sons, 2016. Vol. 9, no 5, 610-617 p.
National Category
Industrial Biotechnology
URN: urn:nbn:se:kth:diva-193009DOI: 10.1111/1751-7915.12385ScopusID: 2-s2.0-84983317316OAI: diva2:974213

QC 20161010

Available from: 2016-09-26 Created: 2016-09-26 Last updated: 2016-10-10Bibliographically approved

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