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  • 1.
    Abellan-Flos, Marta
    et al.
    Univ Namur, Dept Chim, Lab Chim Bioorgan, Rue Bruxelles 61, B-5000 Namur, Belgium.;PSL Univ, CNRS, ESPCI Paris, Mol Macromol Chem & Mat, 10 Rue Vauquelin, F-75005 Paris, France..
    Timmer, Brian J. J.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi.
    Altun, Samuel
    Attana AB, Bjornnasvagen 21, S-11419 Stockholm, Sweden..
    Aastrup, Teodor
    Attana AB, Bjornnasvagen 21, S-11419 Stockholm, Sweden..
    Vincent, Stephane P.
    Univ Namur, Dept Chim, Lab Chim Bioorgan, Rue Bruxelles 61, B-5000 Namur, Belgium..
    Ramström, Olof
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi. Univ Massachusetts, Dept Chem, One Univ Ave, Lowell, MA 01854 USA.;Linnaeus Univ, Dept Chem & Biomed Sci, SE-39182 Kalmar, Sweden..
    QCM sensing of multivalent interactions between lectins and well-defined glycosylated nanoplatforms2019Inngår i: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 139, artikkel-id 111328Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Quartz crystal microbalance (QCM) methodology has been adopted to unravel important factors contributing to the "cluster glycoside effect" observed in carbohydrate-lectin interactions. Well-defined, glycosylated nanostructures of precise sizes, geometries and functionalization patterns were designed and synthesized, and applied to analysis of the interaction kinetics and thermodynamics with immobilized lectins. The nanostructures were based on Borromean rings, dodecaamine cages, and fullerenes, each of which carrying a defined number of carbohydrate ligands at precise locations. The synthesis of the Borromeates and dodecaamine cages was easily adjustable due to the modular assembly of the structures, resulting in variations in presentation mode. The binding properties of the glycosylated nanoplatforms were evaluated using flow-through QCM technology, as well as hemagglutination inhibition assays, and compared with dodecaglycosylated fullerenes and a monovalent reference. With the QCM setup, the association and dissociation rate constants and the associated equilibrium constants of the interactions could be estimated, and the results used to delineate the multivalency effects of the lectin-nanostructure interactions.

  • 2.
    Adolfsson, Karin H.
    et al.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi. Sch Chem Sci & Engn, Stockholm, Sweden..
    Hassanzadeh, Salman
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi. Sch Chem Sci & Engn, Stockholm, Sweden..
    Hakkarainen, Minna
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi. Sch Chem Sci & Engn, Stockholm, Sweden..
    Value-added carbon products attained through microwave assisted hydrothermal treatment of cellulose and waste paper2016Inngår i: Abstract of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 251Artikkel i tidsskrift (Annet vitenskapelig)
  • 3.
    Ahlquist, Mårten
    et al.
    Technical University of Denmark.
    Nielsen, T E
    Le Quement, S
    Tanner, David
    Technical University of Denmark.
    Norrby, Per-Ola
    Technical Univeristy of Denmark.
    An experimental and theoretical study of the mechanism of stannylcupration of alpha, beta-acetylenic ketones and esters2006Inngår i: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 12, nr 10, s. 2866-2873Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The title reaction has been investigated by experimental and computational (DFT) techniques, and subsequently compared to the corresponding carbocupration reaction, with particular emphasis oil the stereoselectivity. For stannylcupration of an ynone substrate, only the anti-addition product is observed, whereas for the corresponding ynoate substrate, the stereoselectivity can be affected by the reaction conditions: in the presence of methanol as proton donor, the initial syn-addition product can be trapped, whereas a syn/anti mixture is obtained in a non-protic solvent. This is in sharp contrast to the carbocupration of the same ynone substrate with a cyanocuprate (RCu(CN)Li), which is highly selective for syn-addition. The product selectivities can be understood from a detailed computational characterization of the reaction paths, and in particular from the relative stabilities of the vinyl cuprate and allenolate intermediates. It is suggested that the stereodetermining step is protonation of vinyl cuprate intermediates.

  • 4.
    Albertsson, Ann-Christine
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    From design and synthesis to advanced properties and sustainable polymeric materials2017Inngår i: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 253Artikkel i tidsskrift (Annet vitenskapelig)
  • 5.
    Al-Hinai, Muna
    et al.
    Sultan Qaboos Univ, Petr & Chem Engn, Muscat, Oman.;Water Res Ctr, Nanotechnol, Muscat, Oman..
    Sathe, Priyanka
    Water Res Ctr, Nanotechnol, Muscat, Oman.;Sultan Qaboos Univ, Dept Marine Sci & Fisheries, Muscat, Oman..
    Al-Hinai, Ashraf
    Petr Dev Oman LLC, Mat & Corros Dept, Muscat, Oman..
    Al-Abri, Mohammed
    Sultan Qaboos Univ, Petr & Chem Engn, Muscat, Oman.;Water Res Ctr, Nanotechnol, Muscat, Oman..
    Dobretsov, Sergey
    Sultan Qaboos Univ, Dept Marine Sci & Fisheries, Muscat, Oman..
    Dutta, Joydeep
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Funktionella material, FNM.
    Modification of blended polyethersulfone membranes by in-situ growth of zinc oxide nanostructures for prevention of biofouling during water treatment2016Inngår i: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 251Artikkel i tidsskrift (Annet vitenskapelig)
  • 6.
    Aminzadeh, Selda
    et al.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi. KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center.
    Mattsson, Tuve
    KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center. KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    Henriksson, Gunnar
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi. KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center.
    Lindström, Mikael
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi. KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center.
    On the crossflow membrane fractionation of lignoboost kraft lignin: Characterization of low molecular weight fractions2016Inngår i: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 251Artikkel i tidsskrift (Annet vitenskapelig)
  • 7.
    An, Junxue
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Duan, Lele
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Sun, Licheng
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    The Ru complexes containing pyridine-dicarboxylate ligand: electronic effect on their catalytic activity toward water oxidation2011Inngår i: Faraday discussions (Online), ISSN 1359-6640, E-ISSN 1364-5498, Vol. 155, s. 267-275Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Two series of mononuclear ruthenium complexes [Ru(pdc)L-3] (H(2)pdc = 2,6-pyridinedicarboxylic acid; L = 4-methoxypyridine, 1; pyridine, 2; pyrazine, 3) and [Ru(pdc)L-2(dmso)] (dmso = dimethyl sulfoxide; L = 4-methoxypyridine, 4; pyridine, 5) were synthesized and spectroscopically characterized. Their catalytic activity toward water oxidation has been examined using Ce-IV (Ce(NH4)(2)(NO3)(6)) as the chemical oxidant under acidic conditions. Complexes 1, 2 and 3 are capable of catalyzing Ce-IV-driven water oxidation while 4 and 5 are not active. Electronic effects on their catalytic activity were illustrated: electron donating groups increase the catalytic activity.

  • 8.
    Anderson, Mattias
    et al.
    KTH, Skolan för bioteknologi (BIO), Industriell bioteknologi.
    Afewerki, Samson
    Berglund, Per
    KTH, Skolan för bioteknologi (BIO), Industriell bioteknologi.
    Córdova, Armando
    Chemoenzymatic amination of alcohols by combining oxidation catalysts with transaminases in one potManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Chemoenzymatic methods for the amination of alcohols have been developed. The reactions were performed in a one-pot two-step fashion, where the alcohol starting material was first oxidized to the corresponding carbonyl compound and then subsequently converted to the amine product with an enzymatic system based on an amine transaminase. The enzyme system was able to operate in a water/organic solvent two-phase system in the presence of either a heterogeneous palladium(0) catalyst or a homogeneous copper(I) catalyst. High conversions to the product amines were achieved for a range of substituted benzyl alcohols and similar compounds, but unfortunately the use of aliphatic alcohols resulted in lower conversions and secondary alcohols could not be converted to the corresponding amines with this methodology.

  • 9.
    Andersson, Samir
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Sun, Licheng
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    An efficient water oxidation system based on supramolecular assembly of molecular catalyst and cucurbit[7]urilManuskript (preprint) (Annet vitenskapelig)
  • 10.
    Andersson, Samir
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Zou, Dapeng
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Zhang, Rong
    Sun, Shiguo
    Sun, Licheng
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Light driven formation of a supramolecular system with three CB 8 s locked between redox-active Ru(bpy)(3) complexes2009Inngår i: Organic and biomolecular chemistry, ISSN 1477-0520, E-ISSN 1477-0539, Vol. 7, nr 17, s. 3605-3609Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Three CB[8]s have been reversibly locked between two Ru(bpy)(3)-viologen complexes by light driven electron transfer reactions.

  • 11. Andre, Sabine
    et al.
    Pei, Zichao
    KTH, Skolan för kemivetenskap (CHE), Kemi.
    Siebert, Hans-Christian
    Ramström, Olof
    KTH, Skolan för kemivetenskap (CHE), Kemi.
    Gabius, Hans-Joachim
    Glycosyldisulfides from Dynamic Combinatorial Libraries as O-Glycoside Mimetics for Plant and Endogenous Lectins: Their Reactivities in Solid-Phase and Cell Assays and Conformational Analysis by Molecular Dynamics Simulations2006Inngår i: Bioorganic & Medicinal Chemistry, ISSN 0968-0896, Vol. 14, s. 6314-6326Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Dynamic combinatorial library design exploiting the thiol-disulfide exchange readily affords access to glycosyldisulfides. In order to reveal lectin-binding properties of this type of non-hydrolyzable sugar derivative, libraries originating from a mixture of common building blocks of natural glycans and thiocompounds were tested against three plant agglutinins with specificity to galactose, fucose or N-acetylgalactosamine, respectively, in a solid-phase assay. Extent of lectin binding to matrix-immobilized neoglycoprotein presenting the cognate sugar could be reduced, and evidence for dependence on type of carbohydrate was provided by dynamic deconvolution. Glycosyldisulfides also maintained activity in assays of increased physiological relevance, that is, using native tumor cells and also adding to the test panel an endogenous lectin (galectin-3) involved in tumor spread and cardiac dysfunction. N-Acetylgalactosamine was pinpointed as the most important building block of libraries for the human lectin and the digalactoside as most potent compound acting on the toxic mistletoe agglutinin which is closely related to the biohazard ricin. Because this glycosyldisulfide, which even surpasses lactose in inhibitory capacity, rivals thiodigalactoside as inhibitor, their degrees of intramolecular flexibility were comparatively analyzed by computational calculations. Molecular dynamics runs with explicit consideration of water molecules revealed a conspicuously high degree of potential for shape alterations by the disulfide's three-bond system at the interglycosidic linkage. The presented evidence defines glycosyldisulfides as biologically active ligands for lectins

  • 12.
    Angelin, Marcus
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Discovery-Oriented Screening of Dynamic Systems: Combinatorial and Synthetic Applications2010Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    This thesis is divided into six parts, all centered around the development of dynamic (i.e., reversibly interacting) systems of molecules and their applications in dynamic combinatorial chemistry (DCC) and organic synthesis.

    Part one offers a general introduction, as well as a more detailed description of DCC, being the central concept of this thesis. Part two explores the potential of the nitroaldol reaction as a tool for constructing dynamic systems, employing benzaldehyde derivatives and nitroalkanes. This reaction is then applied in part three where a dynamic nitroaldol system is resolved by lipase-catalyzed transacylation, selecting two out of 16 components.

    In part four, reaction and crystallization driven DCC protocols are developed and demonstrated. The discovery of unexpected crystalline properties of certain pyridine β-nitroalcohols is used to resolve a dynamic system and further expanded into asynthetic procedure. Furthermore, a previously unexplored tandem nitroaldol-iminolactone rearrangement reaction between 2-cyanobenzaldehyde and primarynitroalkanes is used for the resolution of dynamic systems. It is also coupled with diastereoselective crystallization to demonstrate the possibility to combine several selection processes. The mechanism of this reaction is investigated and a synthetic protocol is developed for asymmetric synthesis of 3-substituted isoindolinones.

    Part five continues the exploration of tandem reactions by combining dynamic hemithioacetal or cyanohydrin formation with intramolecular cyclization to synthesize a wide range of 3-functionalized phthalides.

    Finally, part six deals with the construction of a laboratory experiment to facilitate the introduction of DCC in undergraduate chemistry education. The experiment is based on previous work in our group and features an acetylcholinesterase-catalyzed resolution of a dynamic transthioacylation system.

  • 13.
    Angelin, Marcus
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Fischer, Andreas
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Ramström, Olof
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Crystallization-induced secondary selection from a tandem driven dynamic combinatorial resolution process2008Inngår i: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 73, nr 9, s. 3593-3595Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Crystallization-induced secondary selection from a tandem driven dynamic combinatorial library is presented. In a one-pot experiment, an initial nitroaldol equilibrium was kinetically driven by a tandem reaction resulting in a subsequent dynamic library of diastereoisomers. This library was then further driven by a phase change, resulting in amplification and isolation of a highly diastereomerically enriched and synthetically interesting isoindolinone.

  • 14.
    Angelin, Marcus
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Larsson, Rikard
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Vongvilai, Pornrapee
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Ramström, Olof
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Introducing Dynamic Combinatorial Chemistry: Probing the Substrate Selectivity of Acetylcholinesterase2010Inngår i: Journal of Chemical Education, ISSN 0021-9584, E-ISSN 1938-1328, Vol. 87, nr 11, s. 1248-1251Artikkel i tidsskrift (Fagfellevurdert)
  • 15.
    Angelin, Marcus
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi.
    Rahm, Martin
    KTH, Skolan för kemivetenskap (CHE), Kemi.
    Fischer, Andreas
    KTH, Skolan för kemivetenskap (CHE), Kemi.
    Brinck, Tore
    KTH, Skolan för kemivetenskap (CHE), Kemi.
    Ramström, Olof
    KTH, Skolan för kemivetenskap (CHE), Kemi.
    Diastereoselective One-Pot Tandem Synthesis of 3-Substituted Isoindolinones: A Mechanistic Investigation2010Inngår i: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 75, nr 17, s. 5882-5887Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The mechanism of a base-catalyzed one-pot reaction of 2-cyanobenzaldehyde and primary nitroalkanes, to produce 3-substituted isoindolinones, has been investigated. A route starting with a nitroaldol (Henry) reaction, followed by a subsequent cyclization and rearrangement, was supported by intermediate analogue synthesis and DFT calculations. Direct diastereoselective crystallization from the reaction mixture was also achieved and studied for a number of substrates. Furthermore, the 3-substituted isoindolinones are an interesting group of compounds, both present important natural products, as well as being precursors to other valuable building blocks.

  • 16.
    Ansari, Farhan
    KTH.
    Cellulose fibers reinforced thermoset composites - micro vs nano2016Inngår i: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 251Artikkel i tidsskrift (Annet vitenskapelig)
  • 17. Ashitani, T.
    et al.
    Kusumoto, N.
    Borg-Karlson, Anna Karin
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Fujita, K.
    Takahashi, K.
    Antitermite activity of β-caryophyllene epoxide and episulfide2013Inngår i: Zeitschrift für Naturforschung C - A Journal of Biosciences, ISSN 0939-5075, E-ISSN 1865-7125, Vol. 68 C, nr 7-8, s. 302-306Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Caryophyllene-6,7-epoxide and caryophyllene-6,7-episulfide can be easily synthesized from β-caryophyllene by autoxidation or episulfidation. The bioactivities of β-caryophyllene and its derivatives were investigated against the subterranean termite Reticulitermes speratus Kolbe. The antifeedant, feeding, and termiticidal activities of each compound were tested using no-choice, dual-choice, and non-contact methods. Antitermitic activities were not shown by β-caryophyllene, but were observed for the oxide and sulfide derivatives. Caryophyllene- 6,7-episulfide showed especially high antifeedant and termiticidal activities. Thus, naturally abundant, non-bioactive β-caryophyllene can be easily converted into an antitermite reagent via a non-biological process.

  • 18.
    Axelsson, Karolin
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Chemical signals in interactions between Hylobius abietis and associated bacteria2016Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The pine weevil (Hylobius abietis L.) is one of the two topmost economically important insect pests in Swedish conifer forests. The damage increase in areas were the silvicultural practice is to use clear cuttings were the insects gather and breed. During egglaying the female protects her offspring by creating a cave in roots and stumps were she puts her egg and covers it with frass, a mixture of weevil feces and chewed bark. Adult pine weevils have been observed to feed on the other side of the egg laying site and antifeedant substance has been discovered in the feces of the pine weevil. We think it is possible that microorganisms present in the frass contribute with antifeedant/repellent substances. Little is known about the pine weevils associated bacteria community and their symbiotic functions. In this thesis the bacterial community is characterized in gut and frass both from pine weevils in different populations across Europe as well as after a 28 day long diet regime on Scots pine, silver birch or bilberry. Volatile substances produced by isolated bacteria as well as from a consortium of microorganisms were collected with solid phase micro extraction (SPME) and analyzed with GC-MS. The main volatiles were tested against pine weevils using a two-choice test. Wolbachia, Rahnella aquatilis, Serratia and Pseudomonas syringae was commonly associated with the pine weevil. 2-Methoxyphenol, 2-phenylethanol, 3-methyl-1-butanol were found in the headspace from Rahnella aquatilis when grown in substrate containing pine bark. 2-Methoxyphenol and 3-methyl-1-butanol, phenol and methyl salicylate were found in pine feces. Birch and bilberry feces emitted mainly linalool oxides and bilberry emitted also small amounts of 2-phenylethanol.

    A second part of the thesis discusses the role of fungi in forest insect interactions and the production of oxygenated monoterpenes as possible antifeedants. Spruce bark beetles (Ips typhographus L.) aggregate with the help of pheromones and with collected forces they kill weakened adult trees as a result of associated fungi growth and larval development. A fungi associated with the bark beetle, Grosmannia europhoides, was shown to produce de novo 2-methyl-3-buten-2-ol, the major component of the spruce bark beetle aggregation pheromone. Chemical defense responses against Endoconidiophora polonica and Heterobasidion parviporum were investigated using four clones of Norway spruce with different susceptibility to Heterobasidion sp. Clone specific differences were found in induced mono-, sesqui and diterpenes. A number of oxygenated monoterpenes which are known antifeedants for the pine weevil were produced in the infested areas.

  • 19.
    Axelsson, Karolin
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Konstanzer, Vera
    Kuttuva Rajarao, Guna
    KTH, Skolan för bioteknologi (BIO), Industriell bioteknologi.
    Terenius, Olle
    Dep of Ecology, SLU.
    Seriot, Lisa
    Nordenhem, Henrik
    Dep. of Ecology, SLU.
    Nordlander, Göran
    Dep. of Ecology, SLU.
    Borg-Karlson, Anna-Karin
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Antifeedants produced by bacteria associated to the gut of the pine weevil (Hylobius abietis)Manuskript (preprint) (Annet vitenskapelig)
  • 20.
    Axelsson, Karolin
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Nilsson, Louise
    Nordlander, Göran
    Dep. of Ecology, SLU.
    Borg-Karlson, Anna-Karin
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Terenius, Olle
    Dep of Ecology, SLU.
    Do pine weevil microbiota and corresponding volatiles change due to selective feeding?Manuskript (preprint) (Annet vitenskapelig)
  • 21.
    Axelsson, Karolin
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Zendegi-Shiraz, Amene
    Swedjemark, Gunilla
    Borg-Karlson, Anna-Karin
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Zhao, Tao
    KTH, Skolan för kemivetenskap (CHE), Kemi.
    Clone specific chemical defense responses in Norway spruce to infestations by two pathogenic fungi2016Inngår i: Forest Pathology, ISSN 1437-4781, E-ISSN 1439-0329Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    Heterobasidion parviporum (Hp) were investigated using four clones of Norway spruce (Picea abies) with different susceptibility to Heterobasidion sp. Eight year old trees were inoculated with Ep and Hp to minimize the variation due to environment. After three weeks the bark tissue at the upper border of the inoculation hole were extracted with hexane and analyzed by GC-MS. Both treatment and clonal differences were found based on induced mono-, sesqui- and diterpenes. In addition, the Hp produced toxin, fomanoxin, was identified in lowest amount in the most Hp susceptible clone. The clonal trees seem to use different defense strategies towards the two fungi. One of the clones was able to induce strong chemical defense against both fungi, one clone induced chemical defense only against Ep and the most susceptible clone exhibited the least capacity to produce an effective defense against Ep and Hp. Two diterpenes were found to be distinctly different between clones with different susceptibilities, which can be used as chemical indication of Norway spruce resistance against fungi.

  • 22.
    Azeem, Muhammad
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Microbes Associated with Hylobius abietis: A Chemical and Behavioral Study2013Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    This thesis is based on three inter-related studies: the first part deals with the microbial consortium, the identification of microbes and their volatiles, the second part deals with the study of bio-chemical control methods of two conifer pests; the pine weevil Hylobius abietis (L.) and the root rot fungi Heterobasidion spp., and the third part describes the production of styrene by a fungus using forest waste.The large pine weevil (Hylobius abietis L.) is an economically important pest insect of conifers in reforestation areas of Europe and Asia. The female weevils protect their eggs from feeding conspecifics by adding frass (mixture of weevil feces and chewed bark) along with the eggs. In order to understand the mechanism behind frass deposition at the egg laying site and to find repellents/antifeedants for pine weevils, microbes were isolated from the aseptically collected pine weevil frass. Microbial produced volatile organic compounds (VOCs) were collected by solid phase micro extraction and analyzed by GC-MS after cultivating them on weevil frass broth. The major VOCs were tested against pine weevils using a multi-choice olfactometer. Ewingella sp., Mucor racemosus, Penicillium solitum, P. expansum, Ophiostoma piceae, O. pluriannulatum, Debaryomyces hansenii and Candida sequanensis were identified as abundant microbes. Styrene, 6-protoilludene, 1-octene-3-ol, 3-methylanisole, methyl salicylate, 2-methoxyphenol and 2-methoxy-4-vinylphenol were the VOCs of persistently isolated microbes. In behavioral bioassay, methyl salicylate, 3-methylanisole and styrene significantly reduced the attraction of pine weevils to their host plant volatiles. Heterobasidion spp. are severe pathogenic fungi of conifers that cause root and butt rot in plants. Bacterial isolates were tested for the antagonistic activity against fungi on potato dextrose agar. Bacillus subtilis strains significantly inhibited the growth of H. annosum and H. parviporum. Styrene is an industrial chemical used for making polymeric products, currently produced from fossil fuel. A strain of Penicillium expansum isolated from pine weevil frass was investigated for the production of styrene using forest waste. Grated pine stem bark and mature oak bark supplemented with yeast extract produced greater amounts of styrene compared to potato dextrose broth.

  • 23.
    Azeem, Muhammad
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi. Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
    Barba Aliaga, Marina
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Industriell bioteknologi.
    Borg-Karlson, Anna-Karin
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Organisk kemi. Division of Organic Chemistry, Institute of Technology, Tartu University, Tartu 50411, Estonia.
    Terenius, O.
    Broberg, A.
    Rajarao, Gunaratna Kuttuva
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Industriell bioteknologi.
    Heterobasidion-growth inhibiting Bacillus subtilis A18 exhibits medium- and age-dependent production of lipopeptides2019Inngår i: Microbiology Research, ISSN 0944-5013, E-ISSN 1618-0623, Vol. 223-225, s. 129-136Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Heterobasidion annosum s.s. and H. parviporum are severe pathogens of conifers causing butt rot and root rot thus reducing the economic value of timber. Here, the antifungal activity of Bacillus subtilis isolate A18 against these two Heterobasidion species was investigated. Five different culture media with different culture age were investigated to study the effect of substrate composition and culture age for metabolite production. Bacterial cultures and cell-free culture filtrates were tested for antifungal activity. Inhibition of fungal growth was analysed using the agar disc-diffusion method. MALDI-TOF and LC-HRMS analyses were used to identify the antifungal metabolites. Substrate composition and age of culture were found to be active variables with direct effect on the antifungal activity of bacterial culture extracts. High anti-fungal activity was observed when B. subtilis was cultured in PDB, SGB and LB media for four days. Mass-spectrometry analysis showed the presence of lipopeptides in culture filtrates identified as members of the surfactins, polymixins, kurstakins and fengycins. A culture filtrate containing fengycin-type lipopeptides showed the highest bioactivity against Heterobasidion species. Bacterial cultures had higher bioactivity compared to their respective cell free culture filtrates. The results of the present study suggest that B. subtilis A18 is a powerful biocontrol agent against Heterobasidion infections of tree wounds and stumps.

  • 24.
    Bah, Juho
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Metal-Free Catalysis for Efficient Synthesis2014Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The strength of efficient metal-free catalysis will be examined in this thesis. Efforts towards more sustainable processes will be demonstrated through implementation of strategies that meet several of the 12 principles of Green Chemistry.In the first part, a stereoselective total synthesis of multiple alkaloids from the Corynantheine and Ipecac families together with their non-natural analogues will be disclosed. A highly efficient, common synthetic strategy is applied leading to high overall yields starting from easily available starting material. Overall operational simplicity and sustainability have been the main focus. Time-consuming and waste-generating isolations and purifications of intermediates have been minimized, as well as the introduction of protection-group chemistry. Moreover, the first example of the total synthesis of Hydroxydihydrocorynantheol together with its non-natural epimer has been accomplished in multi-gram scale without protection groups and without a single isolation or purification step in high overall yield and diastereoselectivity.In the second part, carbocations will be presented as highly effective and versatile non-metal Lewis acid catalysts. Lewis acidity-tuning of carbocations will be introduced and applied in several reactions to suppress competing reactions. Finally, the broad scope of carbocation catalyzed transformations will be exposed.At large, evident progress has been made towards more sustainable chemistry.

  • 25.
    Bah, Juho
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Naidu, Veluru Ramesh
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Teske, Johannes
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Franzén, Johan
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Carbocations as Lewis Acid Catalysts: Scope and Reactivity2015Inngår i: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 357, nr 1, s. 148-158Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    One class of potential Lewis acids that has received negligible attention as a catalyst is the carbocation. Here we show the potential of triarylmethylium ions as highly powerful Lewis acid catalysts for organic reactions. The Lewis acidity of the triarylmethylium ion can be easily tuned by variation of the electronic properties of the aromatic rings and the catalytic activity of the carbocation is shown to correlate directly to the level of stabilization of the empty p(C)-orbital at the cationic carbon. The versatility of triarylmethylium ions as efficient Lewis acid catalysts for organic reactions is demonstrated in Diels-Alder, aza-Diels-Alder, conjugate addition, halogenation, epoxide rearrangement and intramolecular hetro-ene reactions.

  • 26. Bassanini, Ivan
    et al.
    Hult, Karl
    KTH, Skolan för bioteknologi (BIO), Industriell bioteknologi. CNR, Italy.
    Riva, Sergio
    Dicarboxylic esters: Useful tools for the biocatalyzed synthesis of hybrid compounds and polymers2015Inngår i: Beilstein Journal of Organic Chemistry, ISSN 2195-951X, E-ISSN 1860-5397, Vol. 11, s. 1583-1595Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Dicarboxylic acids and their derivatives (esters and anhydrides) have been used as acylating agents in lipase-catalyzed reactions in organic solvents. The synthetic outcomes have been dimeric or hybrid derivatives of bioactive natural compounds as well as functionalized polyesters.

  • 27. Bednarska, Joanna
    et al.
    Zalesny, Robert
    Tian, Guangjun
    Natarajan Arul, Murugan
    KTH, Skolan för bioteknologi (BIO), Teoretisk kemi och biologi.
    Ågren, Hans
    KTH, Skolan för bioteknologi (BIO), Teoretisk kemi och biologi.
    Bartkowiak, Wojciech
    Nonempirical Simulations of Inhomogeneous Broadening of Electronic Transitions in Solution: Predicting Band Shapes in One- and Two-Photon Absorption Spectra of Chalcones2017Inngår i: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 22, nr 10, artikkel-id 1643Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We have examined several approaches relying on the Polarizable Embedding (PE) scheme to predict optical band shapes for two chalcone molecules in methanol solution. The PE-TDDFT and PERI-CC2 methods were combined with molecular dynamics simulations, where the solute geometry was kept either as rigid, flexible or partly-flexible (restrained) body. The first approach, termed RBMD-PE-TDDFT, was employed to estimate the inhomogeneous broadening for subsequent convolution with the vibrationally-resolved spectra of the molecule in solution determined quantum-mechanically (QM). As demonstrated, the RBMD-PE-TDDFT/QM-PCM approach delivers accurate band widths, also reproducing their correct asymmetric shapes. Further refinement can be obtained by the estimation of the inhomogeneous broadening using the RBMD-PERI-CC2 method. On the other hand, the remaining two approaches (FBMD-PE-TDDFT and ResBMD-PE-TDDFT), which lack quantum-mechanical treatment of molecular vibrations, lead to underestimated band widths. In this study, we also proposed a simple strategy regarding the rapid selection of the exchange-correlation functional for the simulations of vibrationally-resolved one-and two-photon absorption spectra based on two easy-to-compute metrics.

  • 28.
    Bellini, Rosalba
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Magre, Marc
    Biosca, Maria
    Norrby, Per-Ola
    Pamies, Oscar
    Dieguez, Montserrat
    Moberg, Christina
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Conformational Preferences of a Tropos Biphenyl Phosphinooxazoline-a Ligand with Wide Substrate Scope2016Inngår i: ACS Catalysis, ISSN 2155-5435, E-ISSN 2155-5435, Vol. 6, nr 3, s. 1701-1712Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Excellent enantioselectivities are observed in palladium-catalyzed allylic substitutions of a wide range of substrate types and nucleophiles using a bidentate ligand composed of oxazoline and chirally flexible biaryl phosphite elements. This unusually wide substrate scope is shown by experimental and theoretical studies of its eta(3)-allyl and eta(2)-olefin complexes not to be a result of configurational interconversion of the biaryl unit, since the ligand in all reactions adopts an S-a,S configuration on coordination to palladium, but rather the ability of the ligand to adapt the size of the substrate-binding pocket to the reacting substrate. This ability also serves as an explanation to its excellent performance in other types of catalytic processes.

  • 29.
    Bengtsson, Linda
    KTH, Skolan för kemivetenskap (CHE).
    Odorant binding protein and olfactory receptors: plausible role as detectors in an odorant biosensor2011Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
    Abstract [en]

    The development of an inexpensive, portable, stable, sensitive and selective biosensor for detection of odorants is a daunting task. Here, we hypothesized the development of a detector layer composed of the protein groups; the olfactory receptors (ORs) and the odorant binding proteins (OBPs), known to bind odorants in animal sensing. We report the design of 13 OR gene-vector constructs, and their subsequent transformation into

    Escherichia (E.) coli (BL21 (DE3)-STAR-pLysS) strain. Moreover, we report the expression of several ORs into an in vitro wheat germ extract using three separate detergent mixes for protein solubilization.

     

    In addition, we describe the design of an odorant binding protein from the Aenopheles gambiae mosquito PEST strain (OBP-PEST) gene-vector construct under an IPTG (Isopropyl β-D-1-thiogalactopyranoside) inducible promoter. OBP-PEST was heterologously expressed in E.coli with an 8 amino acid long sequence (WSPQFEK) attached C-terminally, via a thrombin cleavage site and a flexible linker (GSSG). The WSPQFEK sequence, commonly referred to as a Strep-tag, enabled subsequent affinity chromatography purification of the protein, via binding to an engineered Streptavidin equivalent. Surprisingly, the OBP-PEST was found to contain a signal sequence leading to its truncation and secretion when expressed in E.coli.

     

    Biophysical analyses were established using Circular Dichroism (CD) for the analysis of two lipocalins: Beta-lactoglobulin (BLG) and OBP-PEST. We studied the solubility, refoldability and the conformational transitions of BLG, as a result of change in solvent, pH and temperature. The secondary structure of OBP-PEST and its thermal stability was investigated.

     

    In conclusion, this thesis work has enabled biophysical analyses of OBP-PEST and future analogs of interest to the development of a stable protein detector layer. Although further experiments are needed to fully characterize the biophysical properties, and to find odorant substrates of OBP-PEST, it was found to be a suitable alternative to ORs in a biosensor detector layer application. More importantly, an inherent OBP-PEST signal sequence was found to mediate protein secretion when expressed heterologously in E.coli. To the best of our knowledge this is the first lipocalin discovered to be secreted upon heterologous expression in E.coli.

     

    We hypothesize that this signal peptide could be used as a means for targeted secretion and, hence, efficient protein purification.

  • 30.
    Benselfelt, Tobias
    et al.
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi. KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center.
    Henschen, Jonatan
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    Pettersson, Torbjörn
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi. KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center.
    Wågberg, Lars
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi. KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center.
    Polyelectrolyte multilayers on differently charged cellulose surfaces2016Inngår i: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 251Artikkel i tidsskrift (Annet vitenskapelig)
  • 31.
    Benyahia Erdal, Nejla
    et al.
    KTH, Skolan för kemivetenskap (CHE). Royal Inst Technol, Sch Chem Sci & Engn, Stockholm, Sweden..
    Adolfsson, Karin H.
    KTH, Skolan för kemivetenskap (CHE). Sch Chem Sci & Engn, Stockholm, Sweden..
    Hakkarainen, Minna
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi. Royal Inst Technol, Stockholm, Sweden..
    Silicone-hydrogel bandage lenses used in conjunction with pharmaceutical eye drops: An uptake and release study2016Inngår i: Abstract of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 251Artikkel i tidsskrift (Annet vitenskapelig)
  • 32.
    Berglund, Jennie
    et al.
    KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center. KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    Bergenstråhle, Malin
    KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center. KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    Vilaplana, Francisco
    KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center. KTH, Skolan för bioteknologi (BIO), Centra, Albanova VinnExcellence Center for Protein Technology, ProNova. KTH, Skolan för bioteknologi (BIO), Glykovetenskap.
    d'Ortoli, Thibault Angles
    Stockholm Univ, Dept Organ Chem, Stockholm, Sweden..
    Widmalm, Goran
    Stockholm Univ, Dept Organ Chem, Stockholm, Sweden..
    Lawoko, Martin
    KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center.
    Henriksson, Gunnar
    KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
    Lindström, Mikael
    KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center. KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    Wohlert, Jakob
    KTH, Skolan för kemivetenskap (CHE), Centra, Wallenberg Wood Science Center. KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    How the flexibility properties of hemicelluloses are affected by the glycosidic bonds between different backbone sugars - A molecular dynamics study2016Inngår i: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 251Artikkel i tidsskrift (Annet vitenskapelig)
  • 33.
    Berglund, Lars
    KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
    Mechanical behavior of nanostructured cellulosic materials2016Inngår i: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 251Artikkel i tidsskrift (Annet vitenskapelig)
  • 34.
    Berglund, P.
    et al.
    Mid Sweden University.
    Holmquist, M.
    Hedenstrom, E.
    Hult, K.
    Hogberg, H. -E
    2-Methylalkanoic acids resolved by esterification catalysed by lipase from Candida rugosa: Alcohol chain length and enantioselectivity1993Inngår i: Tetrahedron Asymmetry, ISSN 09574166 (ISSN), Vol. 4, nr 8, s. 1869-1878Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Enantiomerically pure (R)-2-methyldecanoic acid and (S)-2-methyl-1-decanol were prepared in a multi gram scale by esterification reactions catalysed by lipase from Candida rugosa. The enantiomeric ratios (E-values) were determined as a function of the chain length of the alcohol used as the complementary substrate in cyclohexane. In the resolution of 2-methyldecanoic acid the highest value (E = 37 ± 5) was obtained, when either 2-hexanol, 1-heptanol or 1-octanol were used. In contrast, when resolving 2-methyloctanoic acid, the E-values increased continually with increasing chain length of the alcohol used. 1-Hexadecanol gave the highest value: E > 100. The E-values were determined from the enantiomeric excess (ee) of the product at a conversion below 0.4. After two consecutive esterification reactions enantiomerically pure (R)-2-methyldecanoic acid, >99.8% ee, and after subsequent reduction of the ester produced, (S)-2-methyl-1-decanol, 96.7% ee, were obtained.

  • 35.
    Berglund, P.
    et al.
    Mid Sweden University.
    Holmquist, M.
    Hult, K.
    Hogberg, H. -E
    Alcohols as enantioselective inhibitors in a lipase catalysed esterification of a chiral acyl donor1995Inngår i: Biotechnology Letters, ISSN 01415492 (ISSN), Vol. 17, nr 1, s. 55-60Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Increased reaction rates and increased enantioselectivities were observed with decreased concentrations of n-alkanols when resolving 2-methyldecanoic acid by esterification catalysed by immobilised lipase from Candida rugosa at controlled water activities in cyclohexane. The enantioselectivity was found to be independent of the water activity in the reaction medium at the n-heptanol concentrations investigated. However, when n-decanol was used as the acyl acceptor, not only the alcohol concentration but also the water activity in the reaction medium, influenced the enantioselectivity. The results obtained showed that the low enantioselectivity seen at a high alcohol concentration could be explained by the alcohol influencing the apparent V(max)(S) and V(max)(R) differently.

  • 36.
    Berglund, Per
    KTH, Skolan för bioteknologi (BIO), Biokemi.
    Asymmetric Organic Synthesis with Enzymes: Edited by Vicente Gotor, Ignacio Alfonso and Eduardo Garcia-Urdiales2008Inngår i: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 47, nr 35, s. 6514-6515Artikkel, omtale (Annet vitenskapelig)
  • 37.
    Berglund, Per
    KTH, Tidigare Institutioner, Kemi.
    Candida rugosa lipase as a catalyst in organic media: Enantioselectivity in kinetic resolutions of 2-methylalkanoic acids1995Doktoravhandling, med artikler (Annet vitenskapelig)
  • 38.
    Berglund, Per
    et al.
    KTH, Tidigare Institutioner, Bioteknologi.
    Branneby, Cecilia
    Svedendahl Humble, Maria
    KTH, Skolan för bioteknologi (BIO), Biokemi (stängd 20130101).
    Carlqvist, Peter
    KTH, Skolan för kemivetenskap (CHE), Kemi, Fysikalisk kemi (stängd 20110630).
    Magnusson, Anders
    Hult, Karl
    KTH, Skolan för bioteknologi (BIO), Biokemi (stängd 20130101).
    Brinck, Tore
    KTH, Skolan för kemivetenskap (CHE), Kemi, Fysikalisk kemi (stängd 20110630).
    Aldol and Michael additions catalyzed by a rationally redesigned hydrolytic enzyme2003Inngår i: Abstract of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 226, nr 2, s. U155-U156Artikkel i tidsskrift (Fagfellevurdert)
  • 39. Bergman, J.
    et al.
    Pettersson, B.
    Hasimbegovic, V.
    Svensson, Per H.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Tillämpad fysikalisk kemi. AstraZeneca R&D, Pharmaceut Dev, Sweden.
    Thionations using a P4S10-pyridine complex in solvents such as acetonitrile and dimethyl sulfone2011Inngår i: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 76, nr 6, s. 1546-1553Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Tetraphosphorus decasulfide (P 4S 10) in pyridine has been used as a thionating agent for a long period of time. The moisture-sensitive reagent has now been isolated in crystalline form, and the detailed structure has been determined by X-ray crystallography. The thionating power of this storable reagent has been studied and transferred to solvents such as acetonitrile in which it has proven to be synthetically useful and exceptionally selective. Its properties have been compared with the so-called Lawesson reagent (LR). Particularly interesting are the results from thionations at relatively high temperatures (̃165 °C) in dimethyl sulfone as solvent. Under these conditions, for instance, acridone and 3-acetylindole could quickly be transformed to the corresponding thionated derivatives. Glycylglycine similarly gave piperazinedithione. At these temperatures, LR is inefficient due to rapid decomposition. The thionated products are generally cleaner and more easy to obtain because in the crystalline reagent, impurities which invariably are present in the conventional reagents, P 4S 10 in pyridine or LR, have been removed.

  • 40. Bergman, Jan
    et al.
    Arewang, Carl-Johan
    Svensson, Per H.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Tillämpad fysikalisk kemi. SP Process Development, Sweden .
    Oxidative Ring Expansion of Spirocyclic Oxindole Derivatives2014Inngår i: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 79, nr 19, s. 9065-9073Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Oxidation of the spirocyclic oxindole derivative, isamic acid 1, led to decarboxylation and ring expansion to quinazolino[4,5-b]quinazoline-6,8-dione 7 rather than, as previously believed, its isomer 6. The structure of 7 was confirmed by X-ray crystallography. Condensation of isatin (indole-2,3-dione) and 2-aminobenzamide led to the spirocyclic molecule, spiro[3H-indole-3,2'(1H)quinazoline]-2,4'(1H,3H)dione 8, which was also identified as an intermediate in the oxidation of isamic acid. Mild hydrolysis of 7 gave the 10-membered molecule 22. Isamic acid could easily be converted to N-nitrosoisamic acid, which when heated in ethanol underwent a ring expansion to a hydroximino derivative, 38, of compound 6. The structure of 38 was confirmed by X-ray crystallography.

  • 41.
    Bernin, Diana
    et al.
    Swedish NMR Ctr, Gothenburg, Sweden..
    Bialik, Erik
    Lund Univ, Div Theoret Chem, Lund, Sweden..
    Stenqvist, Bjorn
    Lund Univ, Div Theoret Chem, Lund, Sweden..
    Fang, Yuan
    KTH.
    Ostlund, Asa
    SP Tech Res Inst Sweden, Stockholm, Sweden..
    Furo, Istvan
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi.
    Lindman, Bjorn
    Lund Univ, Chem, Lund, Sweden..
    Lund, Mikael
    Lund Univ, Div Theoret Chem, Lund, Sweden..
    On the ionization of cellulose in aqueous alkali2017Inngår i: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 253Artikkel i tidsskrift (Annet vitenskapelig)
  • 42.
    Blid, Jan
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Asymmetric [2,3]-Sigmatropic Rearrangement of Allylic Ammonium Ylides2005Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The thesis describes the realization of an asymmetric [2,3]-sigmatropic rearrangement of achiral allylic amines. It is divided into two parts; the first part deals with the development of a Lewis acid-mediated [2,3]-sigmatropic rearrangement and the second the asymmetric version thereof. Quaternization of an -amino amide with various Lewis acids established BBr3 and BF3 to be the most appropriate ones. Various allylic amines were subsequently rearranged into the corresponding homoallylic amines in good to excellent syn-diastereoselectivities, revealing the endo-transition state to be the preferred pathway. The structures of the intermediate Lewis acid-amine complexes were confirmed by NMR spectroscopy studies and DFT calculations.

    Based on this investigation a chiral diazaborolidine was chosen as Lewis acid and was shown to efficiently promote the asymmetric [2,3]-sigmatropic rearrangement furnishing homoallylic amines in good yields and excellent enantiomeric excesses. In contrast to the achiral rearrangement mediated by BBr3 and BF3, the asymmetric version gave the opposite major diastereomer, revealing a preference for the exo-transition state in the asymmetric rearrangement. To account for the observed selectivities, a kinetic and thermodynamic pathway was presented. On the basis of a deuterium exchange experiment on a rearranged Lewis acid-amine complex and an NMR spectroscopic investigation, the kinetic pathway was shown to be favored.

  • 43.
    Blid, Jan
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Panknin, Olaf
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Tuzina, Pavel
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Somfai, Peter
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Lewis acid mediated asymmetric 2,3 -sigmatropic rearrangement of allylic amines. Scope and mechanistic investigation2007Inngår i: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 72, nr 4, s. 1294-1300Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    [GRAPHIC] The first asymmetric [2,3]-sigmatropic rearrangement of achiral allylic amines has been realized by quaternization of the amines with an enantiomerically pure diazaborolidine and subsequent treatment with Et3N. The resultant homoallylic amines were obtained in good yields and excellent ee's. The observed diastereo- and enantioselectivities were rationalized by invoking a kinetically controlled process, and support for this model was obtained from an NMR spectroscopic investigation of the chiral Lewis acid-substrate complex. The structure of the Lewis acid-product complex was established by X-ray crystallographic analysis and supported the proposed mechanism.

  • 44.
    Blomkvist, Björn
    KTH, Skolan för kemivetenskap (CHE).
    The application of reversible covalent bonds in catalysis2014Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [en]

    This work has been concerned with the study of ligand exchange of trimethylborate and its  ability to induce temporary intramolecularity. Experiments aimed at understanding the affinity of various alcohols and amines to boron centers by studying the formation of mixed borate species during equilibrium. Furthermore, a variety of reactions has been screened with the aim to perform catalysis by induced intramolecularity through the trimethylborate.

  • 45.
    Blomkvist, Björn
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Organisk kemi.
    Dinér, Peter
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Organisk kemi.
    Mild and Rapid Aniline/HBF4 center dot DEE-Catalysed Formation of Sulfinyl Imines2019Inngår i: ChemistrySelect, ISSN 2365-6549, Vol. 4, nr 25, s. 7431-7436Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The combination of anline and tetrafluoroboric acid diethyl etherate (2.5 mol% and 5 mol%, respectively) significantly accelerates the formation of sulfinyl imines in dichloromethane and isopropylacetate at room temperature compared to previous procedures. A DFT and NMR spectroscopic study shows that the anilinium tetrafluoroborate complex is solvated by sulfinamide molecules in the initial state and that the rate-limiting step of the reaction is the addition of the sulfinamide molecule to the protonated aniline-based imine. In addition, the catalytic system was also utilised in a one-pot, two step reaction, where the in situ formed sulfinyl imine was arylated in a rhodium catalysed reaction with high diastereoselectivity.

  • 46.
    Bo, Xu
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Advanced Organic Hole Transport Materials for Solution-Processed Photovoltaic Devices2015Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Solution-processable photovoltaic devices (PVs), such as perovskite solar cells (PSCs) and solid-state dye-sensitized solar cells (sDSCs) show great potential to replace the conventional silicon-based solar cells for achieving low-cost and large-area solar electrical energy generation in the near future, due to their easy manufacture and high efficiency. Organic hole transport materials (HTMs) play important roles in both PSCs and sDSCs, and thereby can well facilitate the hole separation and transportation, for obtaining high performance solar cells.

    The studies in this thesis aimed to develop advanced small-molecule organic HTMs with low-cost, high hole mobility and conductivity for the achievement of highly efficient, stable and reproducible sDSCs and PSCs. In order to achieve these objectives, two different strategies were utilized in this thesis: the development of new generation HTMs with simple synthetic routes and the introduction of cost-effective p-type dopants to control the charge transport properties of HTMs.

    In Chapter 1 and Chapter 2, a general introduction of the solution-processed sDSCs and PSCs, as well as the characterization methods that are used in this thesis were presented.

    In Chapter 3 and Chapter 4, a series of novel triphenylamine- and carbazole- based HTMs with different oxidation potential, hole mobility, conductivity and molecular size were designed and synthesized, and then systematically applied and investigated in sDSCs and PSCs.

    In Chapter 5, two low-cost and colorless p-type dopants AgTFSI and TeCA were introduced for the organic HTM-Spiro-OMeTAD, which can significantly increase the conductivity of the Spiro-OMeTAD films. The doping effects on the influence of sDSC and PSC device performances were also systematically investigated.

  • 47.
    Borg, Tessie
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Stereoselective Nucleophilic Additions to Aldehydes and Development of New Methodology in Organic Synthesis2013Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    This thesis is divided into four separate parts with nucleophilic addition to aldehydes as the common feature in three of them.

    The first part deals with the investigation of the stereochemical induction and elucidation of the factors that dictate the p-facial selectivities in Mukaiyama aldol addition to a- and a,b-heteroatom substituted aldehydes. An explanation for the unexpected shift from 1,2-anti to 1,2-syn selectivity seen in the reaction when applying nucleophiles of different sizes in the addition to a-chloro aldehydes is offered.

    The next two parts describes the addition of 1,3-bis(silyl)propenes and C3 substituted 1,3-bis(silyl)propenes to aldehydes and the development of two highly stereoselective new methodologies for the construction of 1,3-dienes and 2,3,4,5-tetrasubstituted tetrahydrofuranes, respectively.

    The last part describes the attempts made towards the total synthesis of (±)-aspidophylline A, where the intention was to apply a domino carbopalladation-carbonylation reaction as the key step in the synthetic route.

  • 48.
    Borg, Tessie
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Danielsson, Jakob
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Somfai, Peter
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Mukaiyama aldol addition to α-chloro-substituted aldehydes. Origin of the unexpected syn selectivity.2010Inngår i: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 46, nr 8, s. 1281-1283Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The addition of sterically demanding enolsilanes to alpha-chloro aldehydes results unexpectedly in preferential formation of the anti-PFA product (1,2-syn), while the addition of the corresponding boron enolate furnishes the expected polar Felkin-Anh product (1,2-anti). A stereoinduction model explaining these observations is proposed.

  • 49.
    Borg, Tessie
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Restorp, Per
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Somfai, Peter
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    ORGN 988-Diastereoselective addition of nucleophiles to aldehydes having polar - and -substituents2007Inngår i: Abstract of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 234Artikkel i tidsskrift (Annet vitenskapelig)
  • 50.
    Borg, Tessie
    et al.
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Timmer, Brian
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Somfai, Peter
    KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
    Diastereoselective formation of 2,3,4,5-tetrasubstituted tetrahydrofurans by a Lewis acid promoted addition of C3-substituted 1,3-bis(silyl)propenes to aldehydes2010Manuskript (preprint) (Annet vitenskapelig)
1234567 1 - 50 of 525
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