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  • 1. Altai, Mohamed
    et al.
    Honarvar, Hadis
    Wållberg, Helena
    KTH, School of Biotechnology (BIO), Protein Technology.
    Strand, Joanna
    Varasteh, Zohreh
    Rosestedt, Maria
    Orlova, Anna
    Dunås, Finn
    Sandström, Mattias
    Löfblom, John
    KTH, School of Biotechnology (BIO), Protein Technology.
    Tolmachev, Vladimir
    Ståhl, Stefan
    KTH, School of Biotechnology (BIO), Protein Technology.
    Selection of an optimal cysteine-containing peptide-based chelator for labeling of affibody molecules with (188)Re.2014In: European Journal of Medicinal Chemistry, ISSN 0223-5234, E-ISSN 1768-3254, Vol. 87, p. 519-28Article in journal (Refereed)
    Abstract [en]

    Affibody molecules constitute a class of small (7 kDa) scaffold proteins that can be engineered to have excellent tumor targeting properties. High reabsorption in kidneys complicates development of affibody molecules for radionuclide therapy. In this study, we evaluated the influence of the composition of cysteine-containing C-terminal peptide-based chelators on the biodistribution and renal retention of (188)Re-labeled anti-HER2 affibody molecules. Biodistribution of affibody molecules containing GGXC or GXGC peptide chelators (where X is G, S, E or K) was compared with biodistribution of a parental affibody molecule ZHER2:2395 having a KVDC peptide chelator. All constructs retained low picomolar affinity to HER2-expressing cells after labeling. The biodistribution of all (188)Re-labeled affibody molecules was in general comparable, with the main observed difference found in the uptake and retention of radioactivity in excretory organs. The (188)Re-ZHER2:V2 affibody molecule with a GGGC chelator provided the lowest uptake in all organs and tissues. The renal retention of (188)Re-ZHER2:V2 (3.1 ± 0.5 %ID/g at 4 h after injection) was 55-fold lower than retention of the parental (188)Re-ZHER2:2395 (172 ± 32 %ID/g). We show that engineering of cysteine-containing peptide-based chelators can be used for significant improvement of biodistribution of (188)Re-labeled scaffold proteins, particularly reduction of their uptake in excretory organs.

  • 2.
    Alvarez, Victor
    et al.
    KTH, School of Technology and Health (STH), Medical Engineering, Neuronic Engineering.
    Fahlstedt, Madelen
    KTH, School of Technology and Health (STH), Medical Engineering, Neuronic Engineering.
    Halldin, Peter
    KTH, School of Technology and Health (STH), Medical Engineering, Neuronic Engineering.
    Kleiven, Svein
    KTH, School of Technology and Health (STH), Medical Engineering, Neuronic Engineering.
    Importance of neck muscle tonus in head kinematics during pedestrian accidents2013In: 2013 IRCOBI Conference Proceedings - International Research Council on the Biomechanics of Injury, 2013, p. 747-761Conference paper (Refereed)
    Abstract [en]

    Unprotected pedestrians are an exposed group in the rural traffic and the most vulnerable human body region is the head which is the source of many fatal injuries. This study was performed to gain a better understanding of the influence that the neck muscle tonus has on head kinematics during pedestrian accidents. This was done using a detailed whole body FE model and a detailed FE vehicle model. To determine the influence of the muscle tonus a series of simulations were performed where the vehicle speed, pedestrian posture and muscle tonus were varied. Since the human reaction time for muscle activation is in the order of the collision time, the pedestrian was assumed to be prepared for the oncoming vehicle in order to augment the possible influence of muscle tonus. From the simulations performed, kinematic data such as head rotations, trajectory and velocities were extracted for the whole collision event, as well as velocity and accelerations at head impact. These results show that muscle tonus can influence the head rotation during a vehicle collision and therefore alter the head impact orientation. The level of influence on head rotation was in general lower than when altering the struck leg forward and backward, but in the same order of magnitude for some cases. The influence on head accelerations was higher due to muscle tonus than posture in all cases.

  • 3. Courteille, O.
    et al.
    Ho, Johnson
    KTH, School of Technology and Health (STH), Neuronic Engineering (Closed 20130701).
    Fahlstedt, Madelen
    KTH, School of Technology and Health (STH), Neuronic Engineering (Closed 20130701).
    Fors, U.
    Felländer-Tsai, L.
    Hedman, L.
    Möller, H.
    Face validity of VIS-Ed: A visualization program for teaching medical students and residents the biomechanics of cervical spine trauma2013In: Medicine Meets Virtual Reality 20, IOS Press, 2013, p. 96-102Conference paper (Refereed)
    Abstract [en]

    This RCT study aimed to investigate if VIS-Ed (Visualization through Imaging and Simulation - Education) had the potential to improve medical student education and specialist training in clinical diagnosis and treatment of trauma patients. The participants' general opinion was reported as high in both groups (lecture vs. virtual patient (VP)). Face validity of the VIS-Ed for cervical spine trauma was demonstrated and the VP group reported higher stimulation and engagement compared to the lecture group. No significant difference in the knowledge test between both groups could be observed, confirming our null hypothesis that VIS-Ed was on par with a lecture.

  • 4.
    Eliasson, Kristina
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Företagshälsovårdens arbete med förebyggande arbetsmiljöåtgärder inom fysisk arbetsmiljö: Arbetssätt, metoder och effekter2014Report (Other academic)
    Abstract [sv]

    En av företagshälsovårdens viktigaste uppgifter är att arbeta med primärpreventiva tjänster för att förebygga arbetsrelaterade ohälsa hos sina kundföretag. Det finns generellt sett lite internationell forskning om företagshälsovård och dess förebyggande arbetsmiljöarbete. Denna litteraturstudie syftar till att undersöka hur företagshälsovården arbetar som utförare av arbetsmiljöinterventioner hos olika kundföretag med inriktning på primärprevention gällande fysisk arbetsmiljö. Sju artiklar inkluderades i studien. Resultatet visar att det finns få studier där det tydligt framgår att företagshälsovården är utförare av interventionen. De inkluderade studierna visar att när ett multidisciplinärt team varit involverat samt när interventioner har skett på flera nivåer, det vill säga på organisations-, grupp- och individnivå så har effekten varit positiv. Framgångsrika arbetssätt som testats av företagshälsovården för ett primärpreventivt arbete inom fysisk arbetsmiljö har bland annat inneburit systematiska riskbedömningar och teamarbete tillsammans med kundföretaget.

  • 5.
    Englund-Lehmann, Lena
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Validitet och reliabilitet av ett arbetsbelastningsindex (AI) i en FHV enkät2014Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Abstract

     

    The purpose of this work was to scientifically evaluate the sustainability of parts of  a company-specific survey within the Occupational Health Services (FHV). The service is called HALU which is an abbreviation of the “Work Health and Lifestyle” survey and provided by Feelgood AB. HALU is a questionnaire that is used frequently towards the customer and answered on an individual level with subsequent health interviews and a statement regarding the organization's performance in order to identify the health, lifestyle and working situation of the organization. In this work, questions regarding workloads were evaluated. There were six different workload questions, and the question in this paper were whether these issues had an internal consistency, validity and reliability, and if these issues’ correlation to questions about health during the past year. These analyzes were designed as cross-sectional studies The work also included a longitudinal study in which survey responses from the same individual on two occasions analyzed to see if the responses of workload and health has correlation at two different response times. The material used is a selection from Feelgood database from which includes total includes 130,422 HALU surveys. This sample includes 17,513 surveys from 201007. The study was performed in three steps: Step 1 was a reliability study in which the internal consistency analysis regarding workload questions in the questionnaire . A workload index was created (AI) Stage 2 was a validity study where the correlation coefficient analyzed for correlation between the AI which was calculated in step 1 and the in -depth study of health issues. Step 3 was also a validity study where the correlation coefficient was analyzed in terms of relationships between different survey occasions in the same individual, in order to see if the change in workload results in change in self-perceived health . The result showed that there was strong internal consistency regarding workload issues and that there was correlation between workload and health in a cross section . There were also correlation between survey responses occasions but this was low.

  • 6. Hedman, Leif
    et al.
    Fahlstedt, Madelen
    KTH, School of Technology and Health (STH), Medical Engineering, Neuronic Engineering.
    Schlickum, Marcus
    Möller, Hans
    von Holst, Hans
    KTH, School of Technology and Health (STH), Medical Engineering, Neuronic Engineering.
    Felländer-Tsai, Li
    A pilot evaluation of an educational program that offers visualizations of cervical spine injuries: medical students' self-efficacy increases by training2014In: Informatics for Health and Social Care, ISSN 1753-8157, E-ISSN 1753-8165, Vol. 39, no 1, p. 33-46Article in journal (Refereed)
    Abstract [en]

    In this pilot study, a new method for visualization through imaging and simulation (VIS-Ed) for teaching diagnosis and treatment of cervical spine trauma was formatively evaluated. The aims were to examine if medical students' self-efficacy would change by training using VIS-Ed, and if so these changes were related to how they evaluated the session, and the user interface (UI) of this program. Using a one-group, pre-post course test design 43 Swedish medical students (4th year, 17 males, 26 females) practiced in groups of three participants. Overall the practice and the UI were considered as positive experiences. They judged VIS-Ed as a good interactive scenario-based educational tool. All students' self-efficacy increased significantly by training (p<0.001). Spearman's rank correlation tests revealed that increased self-efficacy was only associated with: how the session was compared to as expected (p<0.007). Students' self-efficacy increased significantly by training, but replication studies should determine if this training effect is gender-related.

  • 7.
    Källskog, Maria
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Tängerstad, Louise
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Finns det arbetsmiljöfaktorer på Arbetsförmedlingen Kundtjänst som förklarar korttidssjukfrånvaron -en Studie med MTO-perspektiv2014Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Sammanfattning

     

    Bakgrund

    Callcenter- verksamhet har vuxit fram snabbt och utvecklats mycket under de senaste årtionden, både internationellt och i Sverige. Det är en verksamhet som innebär många utmaningar i en ofta komplex arbetsmiljö med höga krav på samverkan inom systemperspektivet Människa - Teknik - Organisation. Arbetsförmedlingen tillhandahåller handläggning per telefon via kundtjänster på sju olika orter i Sverige. Korttidssjukfrånvaron ansågs högre i denna verksamhet än i övriga organisationen och målet var att minska den.

     

    Syfte

    Huvudsyftet med denna uppsats var att undersöka om det fanns arbetsmiljöfaktorer på Arbetsförmedlingen Kundtjänst som förklarade korttidssjukfrånvaron. Detta genom att tillämpa ett MTO- perspektiv (Människa - Teknik - Organisation).

     

    Metod

    För att få svar på vår frågeställning tillämpades metodtriangulering genom kvalitativ och kvantitativ datainsamling. En halvdags observation och 16 semistrukturerade intervjuer utfördes på Arbetsförmedlingens kundtjänst i Södertälje och 76 enkäter utfördes på kundtjänsterna i Södertälje och Söderhamn.

     

    Resultat

    Utifrån resultaten i vår studie gick det inte att se samband mellan fysisk arbetsmiljö, höga krav eller låg kontroll och korttidssjukfrånvaro på grund av arbetet. Det fanns dock en statistiskt signifikant skillnad beträffande vissa frågor om arbetsförhållanden och korttidssjukfrånvaro på grund av arbetet.

     

    Slutsats

    På de flesta frågor kunde sambandet mellan korttidssjukfrånvaro och fysisk och psykosocial arbetsmiljö inte påvisas. Däremot fanns en statistisk signifikans i några frågor gällande arbetsförhållanden i denna studie. Det fanns således flera faktorer i arbetsmiljön som skulle kunna förbättras och därmed individens upplevelse av arbetsmiljön. Detta kanske kunde bidra till minskad korttidssjukfrånvaro. Trots att det fanns vissa frågor som påvisade en signifikant skillnad mellan arbetsförhållanden och korttidssjukfrånvaro var det svårt att dra slutsatser på grund av studiens design samt att underlaget var litet. Interventioner i systemkomponenterna Människa – Teknik - Organisation kan vara av värde för att minska korttidssjukfrånvaron.

     

  • 8.
    Kårebrand, Charlotte
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Grundström, Diana
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Upplevd resiliens i två högriskorganisationer2015Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • 9.
    Larsson, Tore J
    KTH, School of Technology and Health (STH), Centres, Centre for Health and Building, CHB.
    The subculture of care and care-related infections: Invited paper to Occupational Risk Prevention Conference 20142014Conference paper (Refereed)
    Abstract [en]

    In Sweden, 10% of all hospitalised patients acquire a care-related infection; between 25 - 35000 patients annually are severely injured due to medical mistakes and between 3000 and 4000 die from erroneous procedures or acquired infections. In a study of the risk of care-related infections in an institution of special accommodation for the aged, journal data and participant observation showed a low level of infection risk, but the risk levels varied significantly between wards and the understanding of hygiene routines varied between staff. It is suggested that hygiene routines be taught as a technical professional skill for physicians, nurses and nursing aides alike.

  • 10.
    Lindqvist, Eva
    et al.
    Karolinska Institutet.
    Larsson, Tore J
    KTH, School of Technology and Health (STH), Centres, Centre for Health and Building, CHB.
    Borell, Lena
    Karolinska Institutet.
    Experienced usability of assistive technology for cognitive support with respect to user goals2015In: NeuroRehabilitation (Reading, MA), ISSN 1053-8135, E-ISSN 1878-6448, Vol. 36, no 1, p. 135-149Article in journal (Refereed)
    Abstract [en]

    Studies have shown that Assistive Technology (AT) for cognitive support can support users in everyday activities. However, whether the AT actually supports the user to achieve their individual goals must further be examined. The study objective was to examine the experienced usability of features in AT for cognitive support for users with cognitive impairment. A content analysis was applied on data from interviews and field notes collected during two six-month interventions in which persons with cognitive impairment tested AT for cognitive support. Features, included in the AT support that enhanced the user's sense of control, were identified as promotional for the achievement of user goals, and some features, such as reminders, were more sensitive to the specific user's perceptions and motives. Also, features related to how the AT was maintained and communicated with other technology were very influential. The results show that easily maintained AT that fits in to the context of use increases the user's sense of control of the AT and thereby promotes the goal achievement and usability of the AT. Further, the usability of the AT is very influenced by contextual factors such as the ordinary mobile network, the Internet, and the operators.

  • 11. Patton, D. A.
    et al.
    McIntosh, A. S.
    Kleiven, Svein
    KTH, School of Technology and Health (STH), Medical Engineering, Neuronic Engineering.
    The biomechanical determinants of concussion: Finite element simulations to investigate brain tissue deformations during sporting impacts to the unprotected head2013In: Journal of Applied Biomechanics, ISSN 1065-8483, E-ISSN 1543-2688, Vol. 29, no 6, p. 721-730Article in journal (Refereed)
    Abstract [en]

    Concussion is an injury of specific interest in collision and contact sports, resulting in a need to develop effective preventive strategies. A detailed finite element model of the human head was used to approximate the regional distribution of tissue deformations in the brain by simulating reconstructions of unhelmeted concussion and no-injury head impacts. The results were evaluated using logistic regression analysis and it was found that angular kinematics, in the coronal plane, and maximum principal strains, in all regions of the brain, were significantly associated with concussion. The results suggested that impacts to the temporal region of the head cause coronal rotations, which render injurious strain levels in the brain. Tentative strain tolerance levels of 0.13, 0.15, and 0.26 in the thalamus, corpus callosum, and white matter, respectively, for a 50% likelihood of concussion were determined by logistic regression. The tentative strain tolerance levels compared well with previously reported results from reconstruction studies of American football and single axon, optic nerve, and brain slice culture model studies. The methods used in the current study provide an opportunity to collect unique kinematic data of sporting impacts to the unprotected head, which can be employed in various ways to broaden the understanding of concussion.

  • 12.
    Ren, Wuwei
    et al.
    KTH, School of Technology and Health (STH), Medical Engineering.
    Valastyán, Iván
    KTH, School of Technology and Health (STH), Medical Engineering.
    Colarieti-Tosti, Massimiliano
    KTH, School of Technology and Health (STH), Medical Engineering.
    Stationary SPECT with multi-layer multiple-pinhole-arrays2012In: 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC), IEEE , 2012, p. 2594-2597Conference paper (Refereed)
    Abstract [en]

    The potential of Multiple Pinhole Arrays (MPA) collimators for developing a Single Photon Emission Computer Tomography (SPECT) system without rotating or moving elements is investigated. A four layer arrangement is proposed and the system performance is evaluated using the simulation toolkit GATE [1]. For a camera with a field of view (FOV) of the order of a human brain (a sphere of radius 100 mm), a sensitivity of 86, 0 cps/MBq and an overall resolution of 5 mm have been estimated, indicating that performances comparable to traditional parallel-hole-collimator cameras can be achieved.

  • 13. Sotres, J.
    et al.
    Pettersson, Torbjörn
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Lindh, L.
    Arnebrant, T.
    NanoWear of Salivary Films vs. Substratum Wettability2012In: Journal of Dental Research, ISSN 0022-0345, E-ISSN 1544-0591, Vol. 91, no 10, p. 973-978Article in journal (Refereed)
    Abstract [en]

    The pellicle serves as a multifunctional protective layer, providing, e.g., lubrication and remineralization and also acting as a diffusion barrier. In addition, since the formation of the pellicle precedes the adhesion of micro-organisms, it is also important as a conditioning film. We present a novel approach to study the influence of the water wettability of solid surfaces on the strength of adsorbed salivary films. It is based on studying the wear resistance of the films with an atomic force microscope operated in the friction force spectroscopy mode. This methodology provides the strength of the films in terms of the forces needed for breaking and removing them. Our results indicate that these forces are highly dependent on the water wettability of the underlying substrata, decreasing with increasing hydrophobicity. Thus, this study provides valuable information for the design of materials exposed in the oral cavity, i.e., materials that will minimize plaque formation and be easy to clean.

  • 14.
    Sundberg, Johan
    et al.
    KTH, Superseded Departments, Speech Transmission and Music Acoustics.
    Ternström, Sten
    KTH, Superseded Departments, Speech Transmission and Music Acoustics.
    Perkins, William H
    University of Southern California.
    Gramming, Patricia
    Malmö General Hospital.
    Long-time average spectrum analysis of phonatory effects of noise and filtered auditory feedback1988In: Journal of Phonetics, ISSN 0095-4470, E-ISSN 1095-8576, Vol. 16, p. 203-219Article in journal (Refereed)
  • 15.
    Ternström, Sten
    KTH, Superseded Departments, Speech Transmission and Music Acoustics.
    Perceptual evaluations of voice scatter in unison choir sounds.1993In: Journal of Voice, ISSN 0892-1997, E-ISSN 1873-4588, Vol. 7, no 2, p. 129-135Article in journal (Refereed)
    Abstract [en]

    The preferences of experiences listerners for pitch and formant frequency dispersion in unison choir sounds were explored using synthesized stimuli. Two types of dispersion were investigated: (a) pitch scatter, which arises when voices in an ensemble exhibit small differences in mean fundamental frequency, and (b) spectral smear, defined as such dispersion of formants 3 to 5 as arises from differences in vocal tract length. Each stimulus represented a choir section of five bass, tenor, alto, or soprano voices, producing the vowel [u], [a], or [ae]. Subjects chose one dispersion level out of six available, selecting the "maximum tolerable" in a first run and the "preferred" in a second run. The listeners were very different in their tolerance for dispersion. Typical scatter choices were 14 cent standard deviation for "tolerable" and 0 or 5 cent for "preferred." The smear choices were less consistent; the standard deviations were 12 and 7%, respectively. In all modes of assessment, the largest dispersion was chosen for the vowel [u] on a bass tone. There was a vowel effect on the smear choices. The effects of voice category were not significant.

  • 16.
    Tängerstad, Louise
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Källskog, Maria
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Finns det arbetsmiljöfaktorer på Arbetsförmedlingen Kundtjänst som förklarar korttidssjukfrånvaron? - En studie med MTO-perspektiv2014Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund

    Callcenter- verksamhet har vuxit fram snabbt och utvecklats mycket under de senaste årtionden, både internationellt och i Sverige. Det är en verksamhet som innebär många utmaningar i en ofta komplex arbetsmiljö med höga krav på samverkan inom systemperspektivet Människa - Teknik - Organisation. Arbetsförmedlingen tillhandahåller handläggning per telefon via kundtjänster på sju olika orter i Sverige. Korttidssjukfrånvaron ansågs högre i denna verksamhet än i övriga organisationen och målet var att minska den.

     

    Syfte

    Huvudsyftet med denna uppsats var att undersöka om det fanns arbetsmiljöfaktorer på Arbetsförmedlingen Kundtjänst som förklarade korttidssjukfrånvaron. Detta genom att tillämpa ett MTO- perspektiv (Människa - Teknik - Organisation).

     

    Metod

    För att få svar på vår frågeställning tillämpades metodtriangulering genom kvalitativ och kvantitativ datainsamling. En halvdags observation och 16 semistrukturerade intervjuer utfördes på Arbetsförmedlingens kundtjänst i Södertälje och 76 enkäter utfördes på kundtjänsterna i Södertälje och Söderhamn.

     

    Resultat

    Utifrån resultaten i vår studie gick det inte att se samband mellan fysisk arbetsmiljö, höga krav eller låg kontroll och korttidssjukfrånvaro på grund av arbetet. Det fanns dock en statistiskt signifikant skillnad beträffande vissa frågor om arbetsförhållanden och korttidssjukfrånvaro på grund av arbetet.

     

    Slutsats

    På de flesta frågor kunde sambandet mellan korttidssjukfrånvaro och fysisk och psykosocial arbetsmiljö inte påvisas. Däremot fanns en statistisk signifikans i några frågor gällande arbetsförhållanden i denna studie. Det fanns således flera faktorer i arbetsmiljön som skulle kunna förbättras och därmed individens upplevelse av arbetsmiljön. Detta kanske kunde bidra till minskad korttidssjukfrånvaro. Trots att det fanns vissa frågor som påvisade en signifikant skillnad mellan arbetsförhållanden och korttidssjukfrånvaro var det svårt att dra slutsatser på grund av studiens design samt att underlaget var litet. Interventioner i systemkomponenterna Människa – Teknik - Organisation kan vara av värde för att minska korttidssjukfrånvaron.

     

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